Effects of gamma-interferon on the endocrine system: results from a phase I study.
Publication
, Journal Article
Goldstein, D; Gockerman, J; Krishnan, R; Ritchie, J; Tso, CY; Hood, LE; Ellinwood, E; Laszlo, J
Published in: Cancer Res
December 1, 1987
Interferon causes profound biological changes when given to patients with cancer and many of these could not be predicted from in vitro or animal model systems. We documented significant changes in hormonal levels for a group of 18 patients who were participants in a Phase I gamma-interferon trial. Adrenocorticotropic hormone, cortisol, and growth hormone were all significantly elevated 2 h after treatment with gamma-interferon, with cortisol and adrenocorticotropic hormone returning to base line by 24 h. A placebo group failed to show this change, suggesting a specific interferon effect. Possible mechanisms for these findings and implications for the use of interferons are discussed.
Duke Scholars
Published In
Cancer Res
ISSN
0008-5472
Publication Date
December 1, 1987
Volume
47
Issue
23
Start / End Page
6397 / 6401
Location
United States
Related Subject Headings
- Thyrotropin
- Oncology & Carcinogenesis
- Interferon-gamma
- Hydrocortisone
- Humans
- Hormones
- Growth Hormone
- Drug Evaluation
- Adrenocorticotropic Hormone
- 3211 Oncology and carcinogenesis
Citation
APA
Chicago
ICMJE
MLA
NLM
Goldstein, D., Gockerman, J., Krishnan, R., Ritchie, J., Tso, C. Y., Hood, L. E., … Laszlo, J. (1987). Effects of gamma-interferon on the endocrine system: results from a phase I study. Cancer Res, 47(23), 6397–6401.
Goldstein, D., J. Gockerman, R. Krishnan, J. Ritchie, C. Y. Tso, L. E. Hood, E. Ellinwood, and J. Laszlo. “Effects of gamma-interferon on the endocrine system: results from a phase I study.” Cancer Res 47, no. 23 (December 1, 1987): 6397–6401.
Goldstein D, Gockerman J, Krishnan R, Ritchie J, Tso CY, Hood LE, et al. Effects of gamma-interferon on the endocrine system: results from a phase I study. Cancer Res. 1987 Dec 1;47(23):6397–401.
Goldstein, D., et al. “Effects of gamma-interferon on the endocrine system: results from a phase I study.” Cancer Res, vol. 47, no. 23, Dec. 1987, pp. 6397–401.
Goldstein D, Gockerman J, Krishnan R, Ritchie J, Tso CY, Hood LE, Ellinwood E, Laszlo J. Effects of gamma-interferon on the endocrine system: results from a phase I study. Cancer Res. 1987 Dec 1;47(23):6397–6401.
Published In
Cancer Res
ISSN
0008-5472
Publication Date
December 1, 1987
Volume
47
Issue
23
Start / End Page
6397 / 6401
Location
United States
Related Subject Headings
- Thyrotropin
- Oncology & Carcinogenesis
- Interferon-gamma
- Hydrocortisone
- Humans
- Hormones
- Growth Hormone
- Drug Evaluation
- Adrenocorticotropic Hormone
- 3211 Oncology and carcinogenesis