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A circuit model for saccadic suppression in the superior colliculus.

Publication ,  Journal Article
Phongphanphanee, P; Mizuno, F; Lee, PH; Yanagawa, Y; Isa, T; Hall, WC
Published in: The Journal of neuroscience : the official journal of the Society for Neuroscience
February 2011

Attenuation of visual activity in the superficial layers (SLs), stratum griseum superficiale and stratum opticum, of the superior colliculus during saccades may contribute to reducing perceptual blur during saccades and also may help prevent subsequent unwanted saccades. GABAergic neurons in the intermediate, premotor, layer (SGI), stratum griseum intermedium, send an inhibitory input to SL. This pathway provided the basis for a model proposing that the SGI premotor cells that project to brainstem gaze centers and discharge before saccades also activate neighboring GABAergic neurons that suppress saccade-induced visual activity in SL. The in vitro method allowed us to test this model. We made whole-cell patch-clamp recordings in collicular slices from either rats or GAD67-GFP knock-in mice, in which GABAergic neurons could be identified by their expression of green fluorescence protein (GFP). Antidromic electrical stimulation of SGI premotor cells was produced by applying pulse currents in which their axons congregate after exiting the superior colliculus. The stimulation evoked monosynaptic EPSCs in SGI GABAergic neurons that project to SL, as would be predicted if these neurons receive excitatory input from the premotor cells. Second, IPSCs were evoked in SL neurons, some of which project to the visual thalamus. These IPSCs were polysynaptically mediated by the GABAergic neurons that were excited by the antidromically activated SGI neurons. These results support the hypothesis that collaterals of premotor neuron axons excite GABAergic neurons that inhibit SL visuosensory cells.

Duke Scholars

Published In

The Journal of neuroscience : the official journal of the Society for Neuroscience

DOI

EISSN

1529-2401

ISSN

0270-6474

Publication Date

February 2011

Volume

31

Issue

6

Start / End Page

1949 / 1954

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
  • Valine
  • Tetrodotoxin
  • Superior Colliculi
  • Sodium Channel Blockers
  • Saccades
  • Reaction Time
  • Rats, Sprague-Dawley
  • Rats
 

Citation

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ICMJE
MLA
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Phongphanphanee, P., Mizuno, F., Lee, P. H., Yanagawa, Y., Isa, T., & Hall, W. C. (2011). A circuit model for saccadic suppression in the superior colliculus. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 31(6), 1949–1954. https://doi.org/10.1523/jneurosci.2305-10.2011
Phongphanphanee, Penphimon, Fengxia Mizuno, Psyche H. Lee, Yuchio Yanagawa, Tadashi Isa, and William C. Hall. “A circuit model for saccadic suppression in the superior colliculus.The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 31, no. 6 (February 2011): 1949–54. https://doi.org/10.1523/jneurosci.2305-10.2011.
Phongphanphanee P, Mizuno F, Lee PH, Yanagawa Y, Isa T, Hall WC. A circuit model for saccadic suppression in the superior colliculus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 Feb;31(6):1949–54.
Phongphanphanee, Penphimon, et al. “A circuit model for saccadic suppression in the superior colliculus.The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, vol. 31, no. 6, Feb. 2011, pp. 1949–54. Epmc, doi:10.1523/jneurosci.2305-10.2011.
Phongphanphanee P, Mizuno F, Lee PH, Yanagawa Y, Isa T, Hall WC. A circuit model for saccadic suppression in the superior colliculus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 Feb;31(6):1949–1954.

Published In

The Journal of neuroscience : the official journal of the Society for Neuroscience

DOI

EISSN

1529-2401

ISSN

0270-6474

Publication Date

February 2011

Volume

31

Issue

6

Start / End Page

1949 / 1954

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
  • Valine
  • Tetrodotoxin
  • Superior Colliculi
  • Sodium Channel Blockers
  • Saccades
  • Reaction Time
  • Rats, Sprague-Dawley
  • Rats