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Variation of human amygdala response during threatening stimuli as a function of 5'HTTLPR genotype and personality style.

Publication ,  Journal Article
Bertolino, A; Arciero, G; Rubino, V; Latorre, V; De Candia, M; Mazzola, V; Blasi, G; Caforio, G; Hariri, A; Kolachana, B; Nardini, M ...
Published in: Biological Psychiatry
June 2005

In the brain, processing of fearful stimuli engages the amygdala, and the variability of its activity is associated with genetic factors as well as with emotional salience. The objective of this study was to explore the relevance of personality style for variability of amygdala response.We studied two groups (n=14 in each group) of healthy subjects categorized by contrasting cognitive styles with which they attribute salience to fearful stimuli: so-called phobic prone subjects who exaggerate potential environmental threat versus so-called eating disorders prone subjects who tend to be much less centered around fear. The two groups underwent functional magnetic resonance imaging (fMRI) at 3T during performance of a perceptual task of threatening stimuli and they were also matched for the genotype of the 5' variable number tandem repeat (VNTR) polymorphism in the serotonin transporter.The fMRI results indicated that phobic prone subjects selectively recruit the amygdala to a larger extent than eating disorders prone subjects. Activity in the amygdala was also independently predicted by personality style and genotype of the serotonin transporter. Moreover, brain activity during a working memory task did not differentiate the two groups.The results of the present study suggest that aspects of personality style are rooted in biological responses of the fear circuitry associated with processing of environmental information.

Duke Scholars

Published In

Biological Psychiatry

DOI

EISSN

1873-2402

ISSN

0006-3223

Publication Date

June 2005

Volume

57

Issue

12

Start / End Page

1517 / 1525

Related Subject Headings

  • Serotonin Plasma Membrane Transport Proteins
  • Reaction Time
  • Psychiatry
  • Photic Stimulation
  • Phobic Disorders
  • Personality
  • Oxygen
  • Neuropsychological Tests
  • Nerve Tissue Proteins
  • Minisatellite Repeats
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bertolino, A., Arciero, G., Rubino, V., Latorre, V., De Candia, M., Mazzola, V., … Scarabino, T. (2005). Variation of human amygdala response during threatening stimuli as a function of 5'HTTLPR genotype and personality style. Biological Psychiatry, 57(12), 1517–1525. https://doi.org/10.1016/j.biopsych.2005.02.031
Bertolino, Alessandro, Giampiero Arciero, Valeria Rubino, Valeria Latorre, Mariapia De Candia, Viridiana Mazzola, Giuseppe Blasi, et al. “Variation of human amygdala response during threatening stimuli as a function of 5'HTTLPR genotype and personality style.Biological Psychiatry 57, no. 12 (June 2005): 1517–25. https://doi.org/10.1016/j.biopsych.2005.02.031.
Bertolino A, Arciero G, Rubino V, Latorre V, De Candia M, Mazzola V, et al. Variation of human amygdala response during threatening stimuli as a function of 5'HTTLPR genotype and personality style. Biological Psychiatry. 2005 Jun;57(12):1517–25.
Bertolino, Alessandro, et al. “Variation of human amygdala response during threatening stimuli as a function of 5'HTTLPR genotype and personality style.Biological Psychiatry, vol. 57, no. 12, June 2005, pp. 1517–25. Epmc, doi:10.1016/j.biopsych.2005.02.031.
Bertolino A, Arciero G, Rubino V, Latorre V, De Candia M, Mazzola V, Blasi G, Caforio G, Hariri A, Kolachana B, Nardini M, Weinberger DR, Scarabino T. Variation of human amygdala response during threatening stimuli as a function of 5'HTTLPR genotype and personality style. Biological Psychiatry. 2005 Jun;57(12):1517–1525.
Journal cover image

Published In

Biological Psychiatry

DOI

EISSN

1873-2402

ISSN

0006-3223

Publication Date

June 2005

Volume

57

Issue

12

Start / End Page

1517 / 1525

Related Subject Headings

  • Serotonin Plasma Membrane Transport Proteins
  • Reaction Time
  • Psychiatry
  • Photic Stimulation
  • Phobic Disorders
  • Personality
  • Oxygen
  • Neuropsychological Tests
  • Nerve Tissue Proteins
  • Minisatellite Repeats