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Evolution of pathogenicity and sexual reproduction in eight Candida genomes.

Publication ,  Journal Article
Butler, G; Rasmussen, MD; Lin, MF; Santos, MAS; Sakthikumar, S; Munro, CA; Rheinbay, E; Grabherr, M; Forche, A; Reedy, JL; Agrafioti, I ...
Published in: Nature
June 4, 2009

Candida species are the most common cause of opportunistic fungal infection worldwide. Here we report the genome sequences of six Candida species and compare these and related pathogens and non-pathogens. There are significant expansions of cell wall, secreted and transporter gene families in pathogenic species, suggesting adaptations associated with virulence. Large genomic tracts are homozygous in three diploid species, possibly resulting from recent recombination events. Surprisingly, key components of the mating and meiosis pathways are missing from several species. These include major differences at the mating-type loci (MTL); Lodderomyces elongisporus lacks MTL, and components of the a1/2 cell identity determinant were lost in other species, raising questions about how mating and cell types are controlled. Analysis of the CUG leucine-to-serine genetic-code change reveals that 99% of ancestral CUG codons were erased and new ones arose elsewhere. Lastly, we revise the Candida albicans gene catalogue, identifying many new genes.

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Published In

Nature

DOI

EISSN

1476-4687

Publication Date

June 4, 2009

Volume

459

Issue

7247

Start / End Page

657 / 662

Location

England

Related Subject Headings

  • Virulence
  • Saccharomyces
  • Reproduction
  • Polymorphism, Genetic
  • Meiosis
  • Genome, Fungal
  • Genes, Fungal
  • General Science & Technology
  • Evolution, Molecular
  • Diploidy
 

Citation

APA
Chicago
ICMJE
MLA
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Butler, G., Rasmussen, M. D., Lin, M. F., Santos, M. A. S., Sakthikumar, S., Munro, C. A., … Cuomo, C. A. (2009). Evolution of pathogenicity and sexual reproduction in eight Candida genomes. Nature, 459(7247), 657–662. https://doi.org/10.1038/nature08064
Butler, Geraldine, Matthew D. Rasmussen, Michael F. Lin, Manuel A. S. Santos, Sharadha Sakthikumar, Carol A. Munro, Esther Rheinbay, et al. “Evolution of pathogenicity and sexual reproduction in eight Candida genomes.Nature 459, no. 7247 (June 4, 2009): 657–62. https://doi.org/10.1038/nature08064.
Butler G, Rasmussen MD, Lin MF, Santos MAS, Sakthikumar S, Munro CA, et al. Evolution of pathogenicity and sexual reproduction in eight Candida genomes. Nature. 2009 Jun 4;459(7247):657–62.
Butler, Geraldine, et al. “Evolution of pathogenicity and sexual reproduction in eight Candida genomes.Nature, vol. 459, no. 7247, June 2009, pp. 657–62. Pubmed, doi:10.1038/nature08064.
Butler G, Rasmussen MD, Lin MF, Santos MAS, Sakthikumar S, Munro CA, Rheinbay E, Grabherr M, Forche A, Reedy JL, Agrafioti I, Arnaud MB, Bates S, Brown AJP, Brunke S, Costanzo MC, Fitzpatrick DA, de Groot PWJ, Harris D, Hoyer LL, Hube B, Klis FM, Kodira C, Lennard N, Logue ME, Martin R, Neiman AM, Nikolaou E, Quail MA, Quinn J, Santos MC, Schmitzberger FF, Sherlock G, Shah P, Silverstein KAT, Skrzypek MS, Soll D, Staggs R, Stansfield I, Stumpf MPH, Sudbery PE, Srikantha T, Zeng Q, Berman J, Berriman M, Heitman J, Gow NAR, Lorenz MC, Birren BW, Kellis M, Cuomo CA. Evolution of pathogenicity and sexual reproduction in eight Candida genomes. Nature. 2009 Jun 4;459(7247):657–662.
Journal cover image

Published In

Nature

DOI

EISSN

1476-4687

Publication Date

June 4, 2009

Volume

459

Issue

7247

Start / End Page

657 / 662

Location

England

Related Subject Headings

  • Virulence
  • Saccharomyces
  • Reproduction
  • Polymorphism, Genetic
  • Meiosis
  • Genome, Fungal
  • Genes, Fungal
  • General Science & Technology
  • Evolution, Molecular
  • Diploidy