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The mating type-specific homeodomain genes SXI1 alpha and SXI2a coordinately control uniparental mitochondrial inheritance in Cryptococcus neoformans.

Publication ,  Journal Article
Yan, Z; Hull, CM; Sun, S; Heitman, J; Xu, J
Published in: Curr Genet
March 2007

In the great majority of sexual eukaryotes, mitochondrial genomes are inherited almost exclusively from a single parent. While many hypotheses have been proposed to explain this phenomenon, very little is known about the genetic elements controlling uniparental mitochondria inheritance. In the bipolar, isogamous basidiomycete yeast Cryptococcus neoformans, progeny from crosses between strains of mating type a (MATa) and mating type alpha (MATalpha) typically inherit mitochondrial DNA (mtDNA) from the MATa parent. We recently demonstrated that a mating type alpha (MATalpha)-specific gene SXI1a, controls mitochondrial inheritance in C. neoformans. Here, we show that another homeodomain gene SXI2a in the alternative mating type MATa is also required for uniparental mtDNA inheritance in this fungus. Disruption of SXI2a resulted in biparental mtDNA inheritance in the zygote population with significant numbers of progeny inheriting mtDNA from the MATa parent, the MATalpha parent, and both the MATa and the MATalpha parents. In addition, progeny from same-sex mating between MATalpha strains showed a biparental mitochondrial inheritance pattern. Our results suggest that SXI1alpha and SXI2a coordinately control uniparental mitochondrial inheritance in C. neoformans.

Duke Scholars

Published In

Curr Genet

DOI

ISSN

0172-8083

Publication Date

March 2007

Volume

51

Issue

3

Start / End Page

187 / 195

Location

United States

Related Subject Headings

  • Mitochondria
  • Microbiology
  • Genes, Mating Type, Fungal
  • Genes, Homeobox
  • Extrachromosomal Inheritance
  • DNA, Mitochondrial
  • Cryptococcus neoformans
  • 3107 Microbiology
  • 3105 Genetics
  • 0605 Microbiology
 

Citation

APA
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ICMJE
MLA
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Yan, Z., Hull, C. M., Sun, S., Heitman, J., & Xu, J. (2007). The mating type-specific homeodomain genes SXI1 alpha and SXI2a coordinately control uniparental mitochondrial inheritance in Cryptococcus neoformans. Curr Genet, 51(3), 187–195. https://doi.org/10.1007/s00294-006-0115-9
Yan, Zhun, Christina M. Hull, Sheng Sun, Joseph Heitman, and Jianping Xu. “The mating type-specific homeodomain genes SXI1 alpha and SXI2a coordinately control uniparental mitochondrial inheritance in Cryptococcus neoformans.Curr Genet 51, no. 3 (March 2007): 187–95. https://doi.org/10.1007/s00294-006-0115-9.
Yan, Zhun, et al. “The mating type-specific homeodomain genes SXI1 alpha and SXI2a coordinately control uniparental mitochondrial inheritance in Cryptococcus neoformans.Curr Genet, vol. 51, no. 3, Mar. 2007, pp. 187–95. Pubmed, doi:10.1007/s00294-006-0115-9.
Journal cover image

Published In

Curr Genet

DOI

ISSN

0172-8083

Publication Date

March 2007

Volume

51

Issue

3

Start / End Page

187 / 195

Location

United States

Related Subject Headings

  • Mitochondria
  • Microbiology
  • Genes, Mating Type, Fungal
  • Genes, Homeobox
  • Extrachromosomal Inheritance
  • DNA, Mitochondrial
  • Cryptococcus neoformans
  • 3107 Microbiology
  • 3105 Genetics
  • 0605 Microbiology