Biochemistry and Immunology of Poly(ethylene glycol)-Modified Adenosine Deaminase (PEG-ADA)
Publication
, Journal Article
Hershfield, MS
Published in: ACS Symposium Series
January 1, 1997
Poly(ethylene glycol)-modified bovine adenosine deaminase (PEG-ADA) was the first PEGylated protein to undergo clinical trial. It has been effective in correcting the toxic biochemical effects of ADA substrates, and in treating the fatal immune deficiency disease caused by ADA deficiency. The experience gained from monitoring PEG-ADA therapy over the past decade provides unique insight into the immunological response to chronic treatment with a PEGylated enzyme.
Duke Scholars
Published In
ACS Symposium Series
DOI
ISSN
0097-6156
Publication Date
January 1, 1997
Volume
680
Start / End Page
145 / 154
Citation
APA
Chicago
ICMJE
MLA
NLM
Hershfield, M. S. (1997). Biochemistry and Immunology of Poly(ethylene glycol)-Modified Adenosine Deaminase (PEG-ADA). ACS Symposium Series, 680, 145–154. https://doi.org/10.1021/bk-1997-0680.ch010
Hershfield, M. S. “Biochemistry and Immunology of Poly(ethylene glycol)-Modified Adenosine Deaminase (PEG-ADA).” ACS Symposium Series 680 (January 1, 1997): 145–54. https://doi.org/10.1021/bk-1997-0680.ch010.
Hershfield MS. Biochemistry and Immunology of Poly(ethylene glycol)-Modified Adenosine Deaminase (PEG-ADA). ACS Symposium Series. 1997 Jan 1;680:145–54.
Hershfield, M. S. “Biochemistry and Immunology of Poly(ethylene glycol)-Modified Adenosine Deaminase (PEG-ADA).” ACS Symposium Series, vol. 680, Jan. 1997, pp. 145–54. Scopus, doi:10.1021/bk-1997-0680.ch010.
Hershfield MS. Biochemistry and Immunology of Poly(ethylene glycol)-Modified Adenosine Deaminase (PEG-ADA). ACS Symposium Series. 1997 Jan 1;680:145–154.
Published In
ACS Symposium Series
DOI
ISSN
0097-6156
Publication Date
January 1, 1997
Volume
680
Start / End Page
145 / 154