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A role for maternal serum screening in detecting chromosomal abnormalities in fetuses with isolated choroid plexus cysts: a prospective multicentre study.

Publication ,  Journal Article
Brown, T; Kliewer, MA; Hertzberg, BS; Ruiz, C; Stamper, TH; Rosnes, J; Lucas, A; Wright, LN; Chescheir, NC; Farmer, L; Jordan, S; Kay, HH
Published in: Prenat Diagn
May 1999

A prospective multicentre study was performed to identify patients with fetal choroid plexus cysts and examine the association between choroid plexus cysts and chromosome abnormalities in the context of variables such as maternal age, serum triple-screen results, race, other prenatally-identified fetal anomalies and cyst characteristics. A total of 18 437 scans were performed in 5 centres and 257 fetuses were identified with choroid plexus cysts. Outcome was available on 250 patients, and of these, chromosomal abnormalities were detected in a total of 13 (5.2 per cent) fetuses. 26 patients in the group had additional ultrasound abnormalities, and 8 of these had fetal chromosome abnormalities. Among the 224 patients with isolated choroid plexus cysts, 5 (2.2 per cent) were found to have chromosomal abnormalities. All cases with identified chromosomal abnormalities were associated with an additional risk factor, such as other ultrasound findings, advanced maternal age or abnormal maternal serum triple-screen results.

Duke Scholars

Published In

Prenat Diagn

ISSN

0197-3851

Publication Date

May 1999

Volume

19

Issue

5

Start / End Page

405 / 410

Location

England

Related Subject Headings

  • Ultrasonography, Prenatal
  • Prospective Studies
  • Prenatal Diagnosis
  • Pregnancy
  • Predictive Value of Tests
  • Obstetrics & Reproductive Medicine
  • North Carolina
  • Humans
  • Fetal Diseases
  • Female
 

Citation

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MLA
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Brown, T., Kliewer, M. A., Hertzberg, B. S., Ruiz, C., Stamper, T. H., Rosnes, J., … Kay, H. H. (1999). A role for maternal serum screening in detecting chromosomal abnormalities in fetuses with isolated choroid plexus cysts: a prospective multicentre study. Prenat Diagn, 19(5), 405–410.
Brown, T., M. A. Kliewer, B. S. Hertzberg, C. Ruiz, T. H. Stamper, J. Rosnes, A. Lucas, et al. “A role for maternal serum screening in detecting chromosomal abnormalities in fetuses with isolated choroid plexus cysts: a prospective multicentre study.Prenat Diagn 19, no. 5 (May 1999): 405–10.
Brown T, Kliewer MA, Hertzberg BS, Ruiz C, Stamper TH, Rosnes J, et al. A role for maternal serum screening in detecting chromosomal abnormalities in fetuses with isolated choroid plexus cysts: a prospective multicentre study. Prenat Diagn. 1999 May;19(5):405–10.
Brown T, Kliewer MA, Hertzberg BS, Ruiz C, Stamper TH, Rosnes J, Lucas A, Wright LN, Chescheir NC, Farmer L, Jordan S, Kay HH. A role for maternal serum screening in detecting chromosomal abnormalities in fetuses with isolated choroid plexus cysts: a prospective multicentre study. Prenat Diagn. 1999 May;19(5):405–410.
Journal cover image

Published In

Prenat Diagn

ISSN

0197-3851

Publication Date

May 1999

Volume

19

Issue

5

Start / End Page

405 / 410

Location

England

Related Subject Headings

  • Ultrasonography, Prenatal
  • Prospective Studies
  • Prenatal Diagnosis
  • Pregnancy
  • Predictive Value of Tests
  • Obstetrics & Reproductive Medicine
  • North Carolina
  • Humans
  • Fetal Diseases
  • Female