Scholars@Duke
Journal cover image

Tolerability of fluoxetine in posttraumatic stress disorder.

Publication ,  Journal Article
Barnett, SD; Tharwani, HM; Hertzberg, MA; Sutherland, SM; Connor, KM; Davidson, JRT
Published in: Prog Neuropsychopharmacol Biol Psychiatry
February 2002
Published version (DOI) Link to item

PURPOSE: In response to earlier reports that raised concerns about the tolerability of fluoxetine in the treatment of posttraumatic stress disorder (PTSD), this study was conducted to systematically delineate treatment-emergent symptoms (TES) associated with fluoxetine treatment of PTSD. METHODS: Sixty-five patients with PTSD enrolled in one of two identical-protocol, 12-week studies and received double-blind fluoxetine or placebo. TES data were obtained using a patient-rated checklist, Severity of Symptoms Scale (SOSS). RESULTS: Only a single patient discontinued treatment due to medication side effects. Compared to placebo, only three statistically significant TES (nausea, diarrhea, and thirst) occurred more frequently in fluoxetine subjects. Fluoxetine was not associated with any statistically significant activating effects. There were no statistically significant associations between the total number of TES experienced and treatment, gender, or comorbid depressive or panic disorders. CONCLUSIONS: This systematic assessment of TES indicated that PTSD patients tolerated fluoxetine well without pronounced activating side effects.

Duke Scholars

Michael Andrew Hertzberg
Author Michael Andrew Hertzberg Psychiatry & Behavioral Sciences, Adult Psychiatry & Psychol ...
Jonathan R.T. Davidson
Author Jonathan R.T. Davidson Psychiatry & Behavioral Sciences, Adult Psychiatry & Psychol ...
Altmetric Attention Stats
Dimensions Citation Stats

Published In

Prog Neuropsychopharmacol Biol Psychiatry

DOI

10.1016/s0278-5846(01)00282-2

ISSN

0278-5846

Publication Date

February 2002

Volume

26

Issue

2

Start / End Page

363 / 367

Location

England

Related Subject Headings

  • Treatment Refusal
  • Stress Disorders, Post-Traumatic
  • Statistics, Nonparametric
  • Selective Serotonin Reuptake Inhibitors
  • Psychiatry
  • Male
  • Humans
  • Fluoxetine
  • Female
  • Double-Blind Method
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Barnett, S. D., Tharwani, H. M., Hertzberg, M. A., Sutherland, S. M., Connor, K. M., & Davidson, J. R. T. (2002). Tolerability of fluoxetine in posttraumatic stress disorder. Prog Neuropsychopharmacol Biol Psychiatry, 26(2), 363–367. https://doi.org/10.1016/s0278-5846(01)00282-2
Barnett, Stewart D., Haresh M. Tharwani, Michael A. Hertzberg, Suzanne M. Sutherland, Kathryn M. Connor, and Jonathan R. T. Davidson. “Tolerability of fluoxetine in posttraumatic stress disorder.” Prog Neuropsychopharmacol Biol Psychiatry 26, no. 2 (February 2002): 363–67. https://doi.org/10.1016/s0278-5846(01)00282-2.
Barnett SD, Tharwani HM, Hertzberg MA, Sutherland SM, Connor KM, Davidson JRT. Tolerability of fluoxetine in posttraumatic stress disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2002 Feb;26(2):363–7.
Barnett, Stewart D., et al. “Tolerability of fluoxetine in posttraumatic stress disorder.” Prog Neuropsychopharmacol Biol Psychiatry, vol. 26, no. 2, Feb. 2002, pp. 363–67. Pubmed, doi:10.1016/s0278-5846(01)00282-2.
Barnett SD, Tharwani HM, Hertzberg MA, Sutherland SM, Connor KM, Davidson JRT. Tolerability of fluoxetine in posttraumatic stress disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2002 Feb;26(2):363–367.
Journal cover image

Published In

Prog Neuropsychopharmacol Biol Psychiatry

DOI

10.1016/s0278-5846(01)00282-2

ISSN

0278-5846

Publication Date

February 2002

Volume

26

Issue

2

Start / End Page

363 / 367

Location

England

Related Subject Headings

  • Treatment Refusal
  • Stress Disorders, Post-Traumatic
  • Statistics, Nonparametric
  • Selective Serotonin Reuptake Inhibitors
  • Psychiatry
  • Male
  • Humans
  • Fluoxetine
  • Female
  • Double-Blind Method