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Histogenesis of dieldrin and DDT-induced hepatocellular carcinoma in Balb/c mice.

Publication ,  Journal Article
Lipsky, MM; Trump, BF; Hinton, DE
Published in: Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer
January 1989

Male, Balb/c mice were fed diets containing dieldrin (10 ppm) and DDT (100-175 ppm) for 75 weeks. Control and treated mice were serially killed and their livers analyzed by histological and histochemical procedures after 2, 4, 8, 16, 36, 52 and 75 weeks of exposure. Mice administered both chlorinated hydrocarbons initially responded with centrolobular hepatocytomegaly. The cells were characterized by decreased glucose-6-phosphatase and succinate dehydrogenase activity. At later periods 52 through 75 weeks, foci of phenotypically-altered hepatocytes were noted. The cells of these lesions were basophilic or clear-staining in hematoxylin and eosin-stained sections and displayed increased gamma glutamyl transpeptidase activity. In mice preloaded with iron dextran, cells of foci were negative for iron when the surrounding parenchyma was siderotic. Hepatocellular adenomas (HA) and carcinomas (HPC) were composed of cells with increased gamma glutamyl transpeptidase and glucose-6-phosphate dehydrogenase and decreased glucose-6-phosphatase and succinate dehydrogenase activity. In iron loaded mice, the cells of HA and HPC did not stain for iron in otherwise siderotic surroundings. Both hepatocellular foci and adenomas may be potential precursors of mouse hepatocellular carcinomas.

Duke Scholars

Published In

Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer

EISSN

2162-6537

ISSN

0731-8898

Publication Date

January 1989

Volume

9

Issue

1

Start / End Page

79 / 93

Related Subject Headings

  • gamma-Glutamyltransferase
  • Oncology & Carcinogenesis
  • Mice, Inbred BALB C
  • Mice
  • Male
  • Liver Neoplasms, Experimental
  • Liver
  • Glucosephosphate Dehydrogenase
  • Dieldrin
  • DDT
 

Citation

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ICMJE
MLA
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Lipsky, M. M., Trump, B. F., & Hinton, D. E. (1989). Histogenesis of dieldrin and DDT-induced hepatocellular carcinoma in Balb/c mice. Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer, 9(1), 79–93.
Lipsky, M. M., B. F. Trump, and D. E. Hinton. “Histogenesis of dieldrin and DDT-induced hepatocellular carcinoma in Balb/c mice.Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer 9, no. 1 (January 1989): 79–93.
Lipsky MM, Trump BF, Hinton DE. Histogenesis of dieldrin and DDT-induced hepatocellular carcinoma in Balb/c mice. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. 1989 Jan;9(1):79–93.
Lipsky, M. M., et al. “Histogenesis of dieldrin and DDT-induced hepatocellular carcinoma in Balb/c mice.Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer, vol. 9, no. 1, Jan. 1989, pp. 79–93.
Lipsky MM, Trump BF, Hinton DE. Histogenesis of dieldrin and DDT-induced hepatocellular carcinoma in Balb/c mice. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. 1989 Jan;9(1):79–93.
Journal cover image

Published In

Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer

EISSN

2162-6537

ISSN

0731-8898

Publication Date

January 1989

Volume

9

Issue

1

Start / End Page

79 / 93

Related Subject Headings

  • gamma-Glutamyltransferase
  • Oncology & Carcinogenesis
  • Mice, Inbred BALB C
  • Mice
  • Male
  • Liver Neoplasms, Experimental
  • Liver
  • Glucosephosphate Dehydrogenase
  • Dieldrin
  • DDT