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Operational standards for CASA instruments.

Publication ,  Journal Article
Davis, RO; Katz, DF
Published in: Journal of andrology
September 1993

Computer-aided sperm analysis (CASA) technology is 7 years old. Over 120 papers have been written that verify the technology or apply it in basic and clinical studies. Most of the technical problems with CASA, such as the dependence of velocity on video frame rate, inaccuracy of count and percent motility for low- and high-concentration specimens, parameter dependence on the number of frames analyzed, sensitivity of the subjective threshold setting, confusion over the presence of debris, and different implementations of algorithms across instruments, still persist. A critical review of the literature reveals that no standard practices are followed within or across instruments. Moreover, no standards have been embraced or recommended by professional societies. Despite its potential to provide objective measurements of specimen and individual sperm parameters, and to automate the laboratory semen analysis, the promise of CASA has not been fulfilled. Unless laboratory medicine defines instrument performance and laboratory standards and co-operates with industry to achieve these goals, CASA technology may remain a research curiosity. This outcome is especially worrisome in the context of increasing requirements for laboratory accuracy, precision, standardization, and accreditation under the Clinical Laboratory Improvement Act of 1988.

Duke Scholars

Published In

Journal of andrology

EISSN

1939-4640

ISSN

0196-3635

Publication Date

September 1993

Volume

14

Issue

5

Start / End Page

385 / 394

Related Subject Headings

  • Reference Standards
  • Obstetrics & Reproductive Medicine
  • Male
  • Infertility, Male
  • Humans
  • Diagnosis, Computer-Assisted
  • 1114 Paediatrics and Reproductive Medicine
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Davis, R. O., & Katz, D. F. (1993). Operational standards for CASA instruments. Journal of Andrology, 14(5), 385–394.
Davis, R. O., and D. F. Katz. “Operational standards for CASA instruments.Journal of Andrology 14, no. 5 (September 1993): 385–94.
Davis RO, Katz DF. Operational standards for CASA instruments. Journal of andrology. 1993 Sep;14(5):385–94.
Davis, R. O., and D. F. Katz. “Operational standards for CASA instruments.Journal of Andrology, vol. 14, no. 5, Sept. 1993, pp. 385–94.
Davis RO, Katz DF. Operational standards for CASA instruments. Journal of andrology. 1993 Sep;14(5):385–394.
Journal cover image

Published In

Journal of andrology

EISSN

1939-4640

ISSN

0196-3635

Publication Date

September 1993

Volume

14

Issue

5

Start / End Page

385 / 394

Related Subject Headings

  • Reference Standards
  • Obstetrics & Reproductive Medicine
  • Male
  • Infertility, Male
  • Humans
  • Diagnosis, Computer-Assisted
  • 1114 Paediatrics and Reproductive Medicine
  • 1103 Clinical Sciences