Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Bone morphogenetic protein signaling is required in the dorsal neural folds before neurulation for the induction of spinal neural crest cells and dorsal neurons.

Publication ,  Journal Article
Stottmann, RW; Klingensmith, J
Published in: Dev Dyn
April 2011

Bone Morphogenetic Protein (BMP) activity has been implicated as a key regulator of multiple aspects of dorsal neural tube development. BMP signaling in the dorsal-most neuroepithelial cells presumably plays a critical role. We use tissue-specific gene ablation to probe the roles of BMPR1A, the type 1 BMP receptor that is seemingly the best candidate to mediate the activities of BMPs on early dorsal neural development. We use two different Cre lines expressed in the dorsal neural folds, one prior to spinal neurulation and one shortly afterward, together with a Bmpr1a conditional null mutation. Our findings indicate that BMPR1A signaling in the dorsal neural folds is important for hindbrain neural tube closure, but suggest it is dispensable for spinal neurulation. Our results also demonstrate a requirement for BMP signaling in patterning of dorsal neural tube cell fate and in neural crest cell formation, and imply a critical period shortly before neural tube closure.

Duke Scholars

Published In

Dev Dyn

DOI

EISSN

1097-0177

Publication Date

April 2011

Volume

240

Issue

4

Start / End Page

755 / 765

Location

United States

Related Subject Headings

  • Spinal Cord
  • Signal Transduction
  • Posterior Horn Cells
  • Neurulation
  • Neural Crest
  • Mice, Transgenic
  • Mice, Inbred C57BL
  • Mice
  • Gene Deletion
  • Embryo, Mammalian
 

Citation

Journal cover image

Published In

Dev Dyn

DOI

EISSN

1097-0177

Publication Date

April 2011

Volume

240

Issue

4

Start / End Page

755 / 765

Location

United States

Related Subject Headings

  • Spinal Cord
  • Signal Transduction
  • Posterior Horn Cells
  • Neurulation
  • Neural Crest
  • Mice, Transgenic
  • Mice, Inbred C57BL
  • Mice
  • Gene Deletion
  • Embryo, Mammalian