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Stimulant-related reductions of growth rates in the PATS.

Publication ,  Journal Article
Swanson, J; Greenhill, L; Wigal, T; Kollins, S; Stehli, A; Davies, M; Chuang, S; Vitiello, B; Skrobala, A; Posner, K; Abikoff, H; Oatis, M ...
Published in: J Am Acad Child Adolesc Psychiatry
November 2006

OBJECTIVE: To investigate growth of children with attention-deficit/hyperactivity disorder (ADHD) in the Preschool ADHD Treatment Study (PATS) before and after initiation of treatment with methylphenidate at titrated doses (average, 14.2 mg/day) administered three times daily, 7 days/week for asymptotically equal to1 year. METHOD: The heights and weights of 140 children with ADHD were measured up to 29 times in the PATS protocol, starting at an average age of 4.4 years. The relationship between standard (z) scores and time on medication was examined using mixed-effect regression to estimate change in relative size (slope). RESULTS: Average relative size at baseline was significantly (p<.0001) greater than zero for z height (+0.45) and z weight (+0.78), indicating greater than expected height (by 2.04 cm) and weight (by 1.78 kg). During treatment, slopes were significantly (p<.0001) less than zero for z height (-0.304/yr) and z weight (-0.530/yr), indicating reduction of growth rates. For 95 children who remained on medication, annual growth rates were 20.3% less than expected for height (5.41 cm/yr-6.79 cm/yr=-1.38 cm/yr) and 55.2% for weight (1.07 kg/yr-2.39 kg/yr=-1.32 kg/yr). CONCLUSIONS: Risks of reduced growth rates should be balanced against expected benefits when preschool-age children are treated with stimulant medication.

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Published In

J Am Acad Child Adolesc Psychiatry

DOI

ISSN

0890-8567

Publication Date

November 2006

Volume

45

Issue

11

Start / End Page

1304 / 1313

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Methylphenidate
  • Male
  • Humans
  • Female
  • Dose-Response Relationship, Drug
  • Developmental & Child Psychology
  • Cluster Analysis
  • Child, Preschool
  • Central Nervous System Agents
 

Citation

APA
Chicago
ICMJE
MLA
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Swanson, J., Greenhill, L., Wigal, T., Kollins, S., Stehli, A., Davies, M., … Wigal, S. (2006). Stimulant-related reductions of growth rates in the PATS. J Am Acad Child Adolesc Psychiatry, 45(11), 1304–1313. https://doi.org/10.1097/01.chi.0000235075.25038.5a
Swanson, James, Laurence Greenhill, Tim Wigal, Scott Kollins, Annamarie Stehli, Mark Davies, Shirley Chuang, et al. “Stimulant-related reductions of growth rates in the PATS.J Am Acad Child Adolesc Psychiatry 45, no. 11 (November 2006): 1304–13. https://doi.org/10.1097/01.chi.0000235075.25038.5a.
Swanson J, Greenhill L, Wigal T, Kollins S, Stehli A, Davies M, et al. Stimulant-related reductions of growth rates in the PATS. J Am Acad Child Adolesc Psychiatry. 2006 Nov;45(11):1304–13.
Swanson, James, et al. “Stimulant-related reductions of growth rates in the PATS.J Am Acad Child Adolesc Psychiatry, vol. 45, no. 11, Nov. 2006, pp. 1304–13. Pubmed, doi:10.1097/01.chi.0000235075.25038.5a.
Swanson J, Greenhill L, Wigal T, Kollins S, Stehli A, Davies M, Chuang S, Vitiello B, Skrobala A, Posner K, Abikoff H, Oatis M, McCRACKEN J, McGOUGH J, Riddle M, Ghuman J, Cunningham C, Wigal S. Stimulant-related reductions of growth rates in the PATS. J Am Acad Child Adolesc Psychiatry. 2006 Nov;45(11):1304–1313.
Journal cover image

Published In

J Am Acad Child Adolesc Psychiatry

DOI

ISSN

0890-8567

Publication Date

November 2006

Volume

45

Issue

11

Start / End Page

1304 / 1313

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Methylphenidate
  • Male
  • Humans
  • Female
  • Dose-Response Relationship, Drug
  • Developmental & Child Psychology
  • Cluster Analysis
  • Child, Preschool
  • Central Nervous System Agents