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Hepatic cyclic AMP generation and ornithine decarboxylase induction by glucagon and beta adrenergic agonists.

Publication ,  Journal Article
Evoniuk, G; Kuhn, CM; Schanberg, SM
Published in: Life Sci
May 27, 1985

The relationship of hepatic ornithine decarboxylase (ODC) activity to cyclic AMP levels and nutritional status was studied in the pre-weanling rat. Previous studies demonstrated that 2 hr without food causes a loss of hepatic ODC induction after glucagon or catecholamine injection. Isoproterenol or glucagon administration produced increased hepatic cyclic AMP and tyrosine aminotransferase activity which were not prevented by nutritional deprivation. Blockade of hepatic beta 2 receptors by the selective antagonist ICI 118,551 prevented increased cAMP levels and ODC activity after isoproterenol administration. Blockade of beta 1 receptors by atenolol did not prevent increased cAMP levels or ODC induction by isoproterenol although it did block activation of cardiac ODC. The phosphodiesterase inhibitor RO20-1724 increased hepatic cAMP levels as well as ODC and TAT activities, although the increase in ODC activity was attenuated by nutritional deprivation. RO20-1724 also potentiated the induction of hepatic ODC after glucagon or isoproterenol administration. Administration of 8-bromo cAMP elevated hepatic ODC activity regardless of nutritional status but also elevated serum levels of growth hormone and corticosterone. Hepatic ODC induction by glucagon or beta 2 agonists can be dissociated from changes in cAMP levels during nutritional deprivation.

Duke Scholars

Published In

Life Sci

DOI

ISSN

0024-3205

Publication Date

May 27, 1985

Volume

36

Issue

21

Start / End Page

2075 / 2083

Location

Netherlands

Related Subject Headings

  • Tyrosine Transaminase
  • Rats, Inbred Strains
  • Rats
  • Pharmacology & Pharmacy
  • Ornithine Decarboxylase
  • Liver
  • Kinetics
  • Isoproterenol
  • Growth Hormone
  • Glucagon
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Evoniuk, G., Kuhn, C. M., & Schanberg, S. M. (1985). Hepatic cyclic AMP generation and ornithine decarboxylase induction by glucagon and beta adrenergic agonists. Life Sci, 36(21), 2075–2083. https://doi.org/10.1016/0024-3205(85)90459-x
Evoniuk, G., C. M. Kuhn, and S. M. Schanberg. “Hepatic cyclic AMP generation and ornithine decarboxylase induction by glucagon and beta adrenergic agonists.Life Sci 36, no. 21 (May 27, 1985): 2075–83. https://doi.org/10.1016/0024-3205(85)90459-x.
Evoniuk G, Kuhn CM, Schanberg SM. Hepatic cyclic AMP generation and ornithine decarboxylase induction by glucagon and beta adrenergic agonists. Life Sci. 1985 May 27;36(21):2075–83.
Evoniuk, G., et al. “Hepatic cyclic AMP generation and ornithine decarboxylase induction by glucagon and beta adrenergic agonists.Life Sci, vol. 36, no. 21, May 1985, pp. 2075–83. Pubmed, doi:10.1016/0024-3205(85)90459-x.
Evoniuk G, Kuhn CM, Schanberg SM. Hepatic cyclic AMP generation and ornithine decarboxylase induction by glucagon and beta adrenergic agonists. Life Sci. 1985 May 27;36(21):2075–2083.
Journal cover image

Published In

Life Sci

DOI

ISSN

0024-3205

Publication Date

May 27, 1985

Volume

36

Issue

21

Start / End Page

2075 / 2083

Location

Netherlands

Related Subject Headings

  • Tyrosine Transaminase
  • Rats, Inbred Strains
  • Rats
  • Pharmacology & Pharmacy
  • Ornithine Decarboxylase
  • Liver
  • Kinetics
  • Isoproterenol
  • Growth Hormone
  • Glucagon