Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and, potentially, other non-Hodgkin lymphoma subtypes.
Publication
, Journal Article
Slager, SL; Camp, NJ; Conde, L; Shanafelt, TD; Achenbach, SJ; Rabe, KG; Kay, NE; Novak, AJ; Call, TG; Bracci, PM; Sille, FMC; Sanchez, S ...
Published in: Br J Haematol
December 2012
A recent meta-analysis of three genome-wide association studies of chronic lymphocytic leukaemia (CLL) identified two common variants at the 6p21.31 locus that are associated with CLL risk. To verify and further explore the association of these variants with other non-Hodgkin lymphoma (NHL) subtypes, we genotyped 1196 CLL cases, 1699 NHL cases, and 2410 controls. We found significant associations between the 6p21.31 variants and CLL risk (rs210134: P = 0·01; rs210142: P = 6·8 × 10(-3)). These variants also showed a trend towards association with some of the other NHL subtypes. Our results validate the prior work and support specific genetic pathways for risk among NHL subtypes.
Duke Scholars
Published In
Br J Haematol
DOI
EISSN
1365-2141
Publication Date
December 2012
Volume
159
Issue
5
Start / End Page
572 / 576
Location
England
Related Subject Headings
- bcl-2 Homologous Antagonist-Killer Protein
- Polymorphism, Single Nucleotide
- Lymphoma, Non-Hodgkin
- Leukemia, Lymphocytic, Chronic, B-Cell
- Immunology
- Humans
- Genotype
- Genome-Wide Association Study
- Genetic Markers
- DNA, Neoplasm
Citation
APA
Chicago
ICMJE
MLA
NLM
Slager, S. L., Camp, N. J., Conde, L., Shanafelt, T. D., Achenbach, S. J., Rabe, K. G., … Cerhan, J. R. (2012). Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and, potentially, other non-Hodgkin lymphoma subtypes. Br J Haematol, 159(5), 572–576. https://doi.org/10.1111/bjh.12070
Slager, Susan L., Nicola J. Camp, Lucia Conde, Tait D. Shanafelt, Sara J. Achenbach, Kari G. Rabe, Neil E. Kay, et al. “Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and, potentially, other non-Hodgkin lymphoma subtypes.” Br J Haematol 159, no. 5 (December 2012): 572–76. https://doi.org/10.1111/bjh.12070.
Slager SL, Camp NJ, Conde L, Shanafelt TD, Achenbach SJ, Rabe KG, et al. Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and, potentially, other non-Hodgkin lymphoma subtypes. Br J Haematol. 2012 Dec;159(5):572–6.
Slager, Susan L., et al. “Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and, potentially, other non-Hodgkin lymphoma subtypes.” Br J Haematol, vol. 159, no. 5, Dec. 2012, pp. 572–76. Pubmed, doi:10.1111/bjh.12070.
Slager SL, Camp NJ, Conde L, Shanafelt TD, Achenbach SJ, Rabe KG, Kay NE, Novak AJ, Call TG, Bracci PM, Sille FMC, Sanchez S, Akers NK, Cunningham JM, Serie DJ, McDonnell SK, Leis JF, Wang AH, Weinberg JB, Glenn M, Link B, Vachon CM, Lanasa MC, Skibola CF, Cerhan JR. Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and, potentially, other non-Hodgkin lymphoma subtypes. Br J Haematol. 2012 Dec;159(5):572–576.
Published In
Br J Haematol
DOI
EISSN
1365-2141
Publication Date
December 2012
Volume
159
Issue
5
Start / End Page
572 / 576
Location
England
Related Subject Headings
- bcl-2 Homologous Antagonist-Killer Protein
- Polymorphism, Single Nucleotide
- Lymphoma, Non-Hodgkin
- Leukemia, Lymphocytic, Chronic, B-Cell
- Immunology
- Humans
- Genotype
- Genome-Wide Association Study
- Genetic Markers
- DNA, Neoplasm