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Short-term calcitriol administration improves calcium homeostasis in adults with cystic fibrosis.

Publication ,  Journal Article
Brown, SA; Ontjes, DA; Lester, GE; Lark, RK; Hensler, MB; Blackwood, AD; Caminiti, MJ; Backlund, DC; Aris, RM
Published in: Osteoporos Int
June 2003

Osteoporosis is a well-defined health risk in cystic fibrosis (CF) patients due to many factors. Vitamin D insufficiency, despite routine cholecalciferol supplementation in CF patients, may contribute to a relative secondary hyperparathyroidism and possibly deficient bone mineralization. An alternate form of vitamin D, calcitriol, was studied to determine short-term effects on fractional calcium absorption and other calciotropic markers in 10 adult CF subjects and in 10 age-, sex- and body mass index (BMI)-matched controls. Serum fractional absorption of (45)Ca was determined after a calcium-containing meal prior to calcitriol intervention. Other measurements included serum parathyroid hormone (PTH), ionized calcium, 25-hydroxyvitamin D (25OHD), 1,25-dihydroxyvitamin D (1,25(OH)(2)D) and urinary calcium:creatinine and N-telopeptide (NTx) concentrations. Both groups were then given calcitriol (0.5 micro g p.o. b.i.d. for 14 days) and restudied following the same protocol. Both groups increased their fractional absorption of (45)Ca after calcitriol ( p=0.015 CF subjects, p=0.001 controls), although calcitriol tended to be less effective in the CF group compared with the controls ( p=0.055). Post-prandial serum PTH concentrations were suppressed compared with baseline in both groups ( p=0.03 CF subjects, p=0.006 controls). Urinary NTx concentrations, a marker for bone resorption, decreased significantly in CF subjects after calcitriol (96.0+/-16.0 vs 63.9+/-12.7 nmol BCE/mmol Cr, p=0.01) and remained unchanged in the control group. The controls had an increase in serum 1,25(OH)(2)D concentrations (69.9+/-4.2 vs 90.7+/-9.6 pmol/l, p=0.02) while there was no significant change in the CF group. Oral calcitriol administration appears to improve markers of calcium balance in adults with CF by increasing fractional absorption of (45)Ca and lowering PTH concentrations, similar to its known effects in healthy subjects, while also suppressing urinary NTx, a marker of bone turnover.

Duke Scholars

Published In

Osteoporos Int

DOI

ISSN

0937-941X

Publication Date

June 2003

Volume

14

Issue

5

Start / End Page

442 / 449

Location

England

Related Subject Headings

  • Risk Factors
  • Peptides
  • Osteoporosis
  • Middle Aged
  • Humans
  • Homeostasis
  • Female
  • Endocrinology & Metabolism
  • Cystic Fibrosis
  • Collagen Type I
 

Citation

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Chicago
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MLA
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Brown, S. A., Ontjes, D. A., Lester, G. E., Lark, R. K., Hensler, M. B., Blackwood, A. D., … Aris, R. M. (2003). Short-term calcitriol administration improves calcium homeostasis in adults with cystic fibrosis. Osteoporos Int, 14(5), 442–449. https://doi.org/10.1007/s00198-002-1331-x
Brown, S. A., D. A. Ontjes, G. E. Lester, R. K. Lark, M. B. Hensler, A. D. Blackwood, M. J. Caminiti, D. C. Backlund, and R. M. Aris. “Short-term calcitriol administration improves calcium homeostasis in adults with cystic fibrosis.Osteoporos Int 14, no. 5 (June 2003): 442–49. https://doi.org/10.1007/s00198-002-1331-x.
Brown SA, Ontjes DA, Lester GE, Lark RK, Hensler MB, Blackwood AD, et al. Short-term calcitriol administration improves calcium homeostasis in adults with cystic fibrosis. Osteoporos Int. 2003 Jun;14(5):442–9.
Brown, S. A., et al. “Short-term calcitriol administration improves calcium homeostasis in adults with cystic fibrosis.Osteoporos Int, vol. 14, no. 5, June 2003, pp. 442–49. Pubmed, doi:10.1007/s00198-002-1331-x.
Brown SA, Ontjes DA, Lester GE, Lark RK, Hensler MB, Blackwood AD, Caminiti MJ, Backlund DC, Aris RM. Short-term calcitriol administration improves calcium homeostasis in adults with cystic fibrosis. Osteoporos Int. 2003 Jun;14(5):442–449.
Journal cover image

Published In

Osteoporos Int

DOI

ISSN

0937-941X

Publication Date

June 2003

Volume

14

Issue

5

Start / End Page

442 / 449

Location

England

Related Subject Headings

  • Risk Factors
  • Peptides
  • Osteoporosis
  • Middle Aged
  • Humans
  • Homeostasis
  • Female
  • Endocrinology & Metabolism
  • Cystic Fibrosis
  • Collagen Type I