Altered renal proximal tubule cell ion homeostasis during diabetes
Publication
, Journal Article
Freudenrich, CC; Hockett, D; Kirk, B; Gilliland, K; Scherer, B; Winter, K; Ingram, P; LeFurgey, A
Published in: Proceedings - Annual Meeting, Microscopy Society of America
December 1, 1993
The use of electron probe x-ray microanalysis (EPXMA) to acquire quantitative micromechanical images of proximal tubule cells from diabetic rats is studied to define how subcellular ion homeostasis is altered during diabetes. During the experiment, proximal tubule cells from streptozotocin-diabetic rats as models experienced several changes in intracellular ionic distributions. These results suggest that basic mechanisms for ion transport in renal tubule cells are changed during diabetes and that glucose-stimulated increases in Na levels alter the distribution of other ions via putative Na-dependent co-transport and counter-transport mechanisms across proximal tubule plasma and organelle membranes.
Duke Scholars
Published In
Proceedings - Annual Meeting, Microscopy Society of America
ISSN
0424-8201
Publication Date
December 1, 1993
Start / End Page
12 / 13
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Freudenrich, C. C., Hockett, D., Kirk, B., Gilliland, K., Scherer, B., Winter, K., … LeFurgey, A. (1993). Altered renal proximal tubule cell ion homeostasis during diabetes. Proceedings - Annual Meeting, Microscopy Society of America, 12–13.
Freudenrich, C. C., D. Hockett, B. Kirk, K. Gilliland, B. Scherer, K. Winter, P. Ingram, and A. LeFurgey. “Altered renal proximal tubule cell ion homeostasis during diabetes.” Proceedings - Annual Meeting, Microscopy Society of America, December 1, 1993, 12–13.
Freudenrich CC, Hockett D, Kirk B, Gilliland K, Scherer B, Winter K, et al. Altered renal proximal tubule cell ion homeostasis during diabetes. Proceedings - Annual Meeting, Microscopy Society of America. 1993 Dec 1;12–3.
Freudenrich, C. C., et al. “Altered renal proximal tubule cell ion homeostasis during diabetes.” Proceedings - Annual Meeting, Microscopy Society of America, Dec. 1993, pp. 12–13.
Freudenrich CC, Hockett D, Kirk B, Gilliland K, Scherer B, Winter K, Ingram P, LeFurgey A. Altered renal proximal tubule cell ion homeostasis during diabetes. Proceedings - Annual Meeting, Microscopy Society of America. 1993 Dec 1;12–13.
Published In
Proceedings - Annual Meeting, Microscopy Society of America
ISSN
0424-8201
Publication Date
December 1, 1993
Start / End Page
12 / 13