Crystallizing thinking about the beta2-adrenergic receptor.
Publication
, Journal Article
Shukla, AK; Sun, J-P; Lefkowitz, RJ
Published in: Mol Pharmacol
May 2008
Two recently determined crystal structures of the human beta2-adrenergic receptor (beta2AR) provide a long-awaited advance in the field of G protein-coupled receptor research. The beta2AR is only the second member of this, the largest family of receptors encoded in the human genome, whose structure has been solved. It follows structures of rhodopsin that were determined previously. Here we set these developments in historical context, discuss the daunting challenges that have been overcome, and appraise what has and has not been learned.
Duke Scholars
Published In
Mol Pharmacol
DOI
EISSN
1521-0111
Publication Date
May 2008
Volume
73
Issue
5
Start / End Page
1333 / 1338
Location
United States
Related Subject Headings
- Structural Homology, Protein
- Rhodopsin
- Receptors, Adrenergic, beta-2
- Protein Structure, Secondary
- Protein Conformation
- Propanolamines
- Pharmacology & Pharmacy
- Humans
- Crystallography, X-Ray
- Carvedilol
Citation
APA
Chicago
ICMJE
MLA
NLM
Shukla, A. K., Sun, J.-P., & Lefkowitz, R. J. (2008). Crystallizing thinking about the beta2-adrenergic receptor. Mol Pharmacol, 73(5), 1333–1338. https://doi.org/10.1124/mol.108.045849
Shukla, Arun K., Jin-Peng Sun, and Robert J. Lefkowitz. “Crystallizing thinking about the beta2-adrenergic receptor.” Mol Pharmacol 73, no. 5 (May 2008): 1333–38. https://doi.org/10.1124/mol.108.045849.
Shukla AK, Sun J-P, Lefkowitz RJ. Crystallizing thinking about the beta2-adrenergic receptor. Mol Pharmacol. 2008 May;73(5):1333–8.
Shukla, Arun K., et al. “Crystallizing thinking about the beta2-adrenergic receptor.” Mol Pharmacol, vol. 73, no. 5, May 2008, pp. 1333–38. Pubmed, doi:10.1124/mol.108.045849.
Shukla AK, Sun J-P, Lefkowitz RJ. Crystallizing thinking about the beta2-adrenergic receptor. Mol Pharmacol. 2008 May;73(5):1333–1338.
Published In
Mol Pharmacol
DOI
EISSN
1521-0111
Publication Date
May 2008
Volume
73
Issue
5
Start / End Page
1333 / 1338
Location
United States
Related Subject Headings
- Structural Homology, Protein
- Rhodopsin
- Receptors, Adrenergic, beta-2
- Protein Structure, Secondary
- Protein Conformation
- Propanolamines
- Pharmacology & Pharmacy
- Humans
- Crystallography, X-Ray
- Carvedilol