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Impact of 25-hydroxyvitamin D deficiency on perioperative parathyroid hormone kinetics and results in patients with primary hyperparathyroidism.

Publication ,  Journal Article
Untch, BR; Barfield, ME; Dar, M; Dixit, D; Leight, GS; Olson, JA
Published in: Surgery
December 2007

BACKGROUND: Successful parathyroidectomy for sporadic primary hyperparathyroidism (pHPT) is predicted by a 50% drop in PTH intra-operatively. Vitamin D is a known inhibitor of PTH secretion and is associated with secondary HPT following adenoma resection. This study examined the impact of 25-hydroxyvitamin D (25OHD) deficiency on perioperative PTH kinetics and outcomes following parathyroidectomy. METHODS: Patients undergoing adenoma resection for pHPT (n=93) had PTH levels recorded at six perioperative time points. Preoperative 25OHD levels were examined retrospectively. Patients were considered 25OHD deficient if the level was <25 ng/mL (n=47) and adequate if the level was >or=25 ng/mL (n=46). RESULTS: Patients with 25OHD-deficiency had significantly higher preoperative calcium, alkaline phosphatase, and PTH levels. PTH levels were significantly higher in 25OHD-deficient patients at incision, at 1 week postop and 1-3 months postop. Average drop in PTH level five minutes post resection was 79+/-14% in the deficient group and 72+/-22% in the non-deficient group (P=.03). 25OHD levels inversely correlated with adenoma weight (P=.03) and postoperative PTH measurements (P=.008). CONCLUSIONS: Sporadic pHPT patients with 25OHD deficiency have higher baseline and postoperative PTH levels compared to non-deficient patients but do not have altered intraoperative PTH kinetics. Vitamin D deficiency is associated with postoperative elevation of PTH.

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Published In

Surgery

DOI

EISSN

1532-7361

Publication Date

December 2007

Volume

142

Issue

6

Start / End Page

1022 / 1026

Location

United States

Related Subject Headings

  • Vitamin D Deficiency
  • Vitamin D
  • Treatment Outcome
  • Surgery
  • Severity of Illness Index
  • Retrospective Studies
  • Prospective Studies
  • Preoperative Care
  • Postoperative Care
  • Parathyroidectomy
 

Citation

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ICMJE
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Untch, B. R., Barfield, M. E., Dar, M., Dixit, D., Leight, G. S., & Olson, J. A. (2007). Impact of 25-hydroxyvitamin D deficiency on perioperative parathyroid hormone kinetics and results in patients with primary hyperparathyroidism. Surgery, 142(6), 1022–1026. https://doi.org/10.1016/j.surg.2007.09.026
Untch, Brian R., Michael E. Barfield, Moahad Dar, Darshana Dixit, George S. Leight, and John A. Olson. “Impact of 25-hydroxyvitamin D deficiency on perioperative parathyroid hormone kinetics and results in patients with primary hyperparathyroidism.Surgery 142, no. 6 (December 2007): 1022–26. https://doi.org/10.1016/j.surg.2007.09.026.
Untch, Brian R., et al. “Impact of 25-hydroxyvitamin D deficiency on perioperative parathyroid hormone kinetics and results in patients with primary hyperparathyroidism.Surgery, vol. 142, no. 6, Dec. 2007, pp. 1022–26. Pubmed, doi:10.1016/j.surg.2007.09.026.
Untch BR, Barfield ME, Dar M, Dixit D, Leight GS, Olson JA. Impact of 25-hydroxyvitamin D deficiency on perioperative parathyroid hormone kinetics and results in patients with primary hyperparathyroidism. Surgery. 2007 Dec;142(6):1022–1026.
Journal cover image

Published In

Surgery

DOI

EISSN

1532-7361

Publication Date

December 2007

Volume

142

Issue

6

Start / End Page

1022 / 1026

Location

United States

Related Subject Headings

  • Vitamin D Deficiency
  • Vitamin D
  • Treatment Outcome
  • Surgery
  • Severity of Illness Index
  • Retrospective Studies
  • Prospective Studies
  • Preoperative Care
  • Postoperative Care
  • Parathyroidectomy