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Enhancement pattern of small hepatocellular carcinoma (HCC) at contrast-enhanced US (CEUS), MDCT, and MRI: intermodality agreement and comparison of diagnostic sensitivity between 2005 and 2010 American Association for the Study of Liver Diseases (AASLD) guidelines.

Publication ,  Journal Article
Furlan, A; Marin, D; Cabassa, P; Taibbi, A; Brunelli, E; Agnello, F; Lagalla, R; Brancatelli, G
Published in: Eur J Radiol
September 2012

OBJECTIVE: To evaluate agreement between contrast-enhanced ultrasound (CEUS), multi-detector row computed tomography (MDCT) and magnetic resonance imaging (MRI) for the assessment of typical and atypical enhancement patterns of small hepatocellular carcinoma (HCC); and to compare diagnostic sensitivity of 2005 and 2010 American Association for the Study of Liver Diseases (AASLD) guidelines. MATERIALS AND METHODS: Between January 2008 and December 2009, we included cirrhotic patients with newly diagnosed 10-20 mm HCC imaged at two contrast-enhanced imaging techniques among CEUS, MDCT, and MRI. Dynamic studies were reviewed by two radiologists to assess enhancement pattern. Percentage of cases with concordant findings and Cohen coefficient (k) were calculated. McNemar's test was used to compare sensitivity between 2005 and 2010 AASLD guidelines. RESULTS: There were 91 patients (69 M; 22 F; mean age, 68 years) with 96 HCCs, studied with a combination of CEUS and MDCT (n=59), CEUS and MRI (n=26), or MDCT and MRI (n=11). Intermodality agreement for assessment of tumor enhancement pattern was 67% (k=0.294, P=0.001). Typical enhancement pattern was detected coincidentally at two imaging modalities in 50 (52%) HCCs. Sensitivity for the diagnosis of HCC increased significantly using the 2010 AASLD (81/96 (84%) vs. 50/96 (52%), P<0.001). CONCLUSIONS: Agreement between two imaging modalities for the detection of typical tumor enhancement pattern was reached in 52% of cases. The 2010 AASLD guidelines significantly increased the sensitivity for the diagnosis of HCC.

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Published In

Eur J Radiol

DOI

EISSN

1872-7727

Publication Date

September 2012

Volume

81

Issue

9

Start / End Page

2099 / 2105

Location

Ireland

Related Subject Headings

  • United States
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Practice Guidelines as Topic
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Liver Neoplasms
  • Italy
  • Humans
 

Citation

APA
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ICMJE
MLA
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Furlan, A., Marin, D., Cabassa, P., Taibbi, A., Brunelli, E., Agnello, F., … Brancatelli, G. (2012). Enhancement pattern of small hepatocellular carcinoma (HCC) at contrast-enhanced US (CEUS), MDCT, and MRI: intermodality agreement and comparison of diagnostic sensitivity between 2005 and 2010 American Association for the Study of Liver Diseases (AASLD) guidelines. Eur J Radiol, 81(9), 2099–2105. https://doi.org/10.1016/j.ejrad.2011.07.010
Furlan, Alessandro, Daniele Marin, Paolo Cabassa, Adele Taibbi, Elena Brunelli, Francesco Agnello, Roberto Lagalla, and Giuseppe Brancatelli. “Enhancement pattern of small hepatocellular carcinoma (HCC) at contrast-enhanced US (CEUS), MDCT, and MRI: intermodality agreement and comparison of diagnostic sensitivity between 2005 and 2010 American Association for the Study of Liver Diseases (AASLD) guidelines.Eur J Radiol 81, no. 9 (September 2012): 2099–2105. https://doi.org/10.1016/j.ejrad.2011.07.010.
Journal cover image

Published In

Eur J Radiol

DOI

EISSN

1872-7727

Publication Date

September 2012

Volume

81

Issue

9

Start / End Page

2099 / 2105

Location

Ireland

Related Subject Headings

  • United States
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Practice Guidelines as Topic
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Liver Neoplasms
  • Italy
  • Humans