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Pregabalin augmentation of antidepressants in patients with accident-related posttraumatic stress disorder: an open label pilot study.

Publication ,  Journal Article
Pae, C-U; Marks, DM; Han, C; Masand, PS; Patkar, AA
Published in: Int Clin Psychopharmacol
January 2009

This study evaluated the efficacy of pregabalin augmentation of antidepressant treatment in patients with posttraumatic stress disorder (PTSD). Nine patients meeting Diagnostic and Statistical Manual, fourth edition criteria for PTSD who were on stable doses of antidepressants were treated open label with flexibly dosed pregabalin for 6 weeks. All patients were assessed with the Short PTSD Rating Interview, Montgomery-Asberg Depression Rating Scale, Patient Global Impression-severity, Visual Analog Scale-pain, and Sheehan Disability Scale at baseline and weeks 2, 4, and 6. Significant reductions were observed in all effectiveness measures from week 4 to the end of the study. In particular, the numerical improvement of the Visual Analog Scale-pain score was most robust (-53.4%, P=0.007). Pregabalin augmentation was effective and well tolerated during the study. Our findings warrant adequately powered, placebo-controlled clinical trials to confirm the usefulness of pregabalin augmentation of antidepressants in patients with PTSD.

Duke Scholars

Published In

Int Clin Psychopharmacol

DOI

ISSN

0268-1315

Publication Date

January 2009

Volume

24

Issue

1

Start / End Page

29 / 33

Location

England

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Treatment Outcome
  • Stress Disorders, Post-Traumatic
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Pregabalin
  • Pilot Projects
  • Middle Aged
  • Male
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Pae, C.-U., Marks, D. M., Han, C., Masand, P. S., & Patkar, A. A. (2009). Pregabalin augmentation of antidepressants in patients with accident-related posttraumatic stress disorder: an open label pilot study. Int Clin Psychopharmacol, 24(1), 29–33. https://doi.org/10.1097/YIC.0b013e32831feea9
Pae, Chi-Un, David M. Marks, Changsu Han, Prakash S. Masand, and Ashwin A. Patkar. “Pregabalin augmentation of antidepressants in patients with accident-related posttraumatic stress disorder: an open label pilot study.Int Clin Psychopharmacol 24, no. 1 (January 2009): 29–33. https://doi.org/10.1097/YIC.0b013e32831feea9.
Pae C-U, Marks DM, Han C, Masand PS, Patkar AA. Pregabalin augmentation of antidepressants in patients with accident-related posttraumatic stress disorder: an open label pilot study. Int Clin Psychopharmacol. 2009 Jan;24(1):29–33.
Pae, Chi-Un, et al. “Pregabalin augmentation of antidepressants in patients with accident-related posttraumatic stress disorder: an open label pilot study.Int Clin Psychopharmacol, vol. 24, no. 1, Jan. 2009, pp. 29–33. Pubmed, doi:10.1097/YIC.0b013e32831feea9.
Pae C-U, Marks DM, Han C, Masand PS, Patkar AA. Pregabalin augmentation of antidepressants in patients with accident-related posttraumatic stress disorder: an open label pilot study. Int Clin Psychopharmacol. 2009 Jan;24(1):29–33.

Published In

Int Clin Psychopharmacol

DOI

ISSN

0268-1315

Publication Date

January 2009

Volume

24

Issue

1

Start / End Page

29 / 33

Location

England

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Treatment Outcome
  • Stress Disorders, Post-Traumatic
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Pregabalin
  • Pilot Projects
  • Middle Aged
  • Male
  • Humans