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Toward effective immunotherapy for the treatment of malignant brain tumors.

Publication ,  Journal Article
Mitchell, DA; Sampson, JH
Published in: Neurotherapeutics
July 2009

The immunologic treatment of cancer has long been heralded as a targeted molecular therapeutic with the promise of eradicating tumor cells with minimal damage to surrounding normal tissues. However, a demonstrative example of the efficacy of immunotherapy in modulating cancer progression is still lacking for most human cancers. Recent breakthroughs in our understanding of the mechanisms leading to full T-cell activation, and recognition of the importance of overcoming tumor-induced immunosuppressive mechanisms, have shed new light on how to generate effective anti-tumor immune responses in humans, and sparked a renewed and enthusiastic effort to realize the full potential of cancer immunotherapy. The immunologic treatment of invasive malignant brain tumors has not escaped this re-invigorated endeavor, and promising therapies are currently under active investigation in dozens of clinical trials at several institutions worldwide. This review will focus on some of the most important breakthroughs in our understanding of how to generate potent anti-tumor immune responses, and some of the clear challenges that lie ahead in achieving effective immunotherapy for the majority of patients with malignant brain tumors. A review of immunotherapeutic strategies currently under clinical evaluation, as well as an outline of promising novel approaches on the horizon, is included to provide perspective on the active and stalwart progress toward effective immunotherapy for the treatment of malignant brain tumors.

Duke Scholars

Published In

Neurotherapeutics

DOI

ISSN

1933-7213

Publication Date

July 2009

Volume

6

Issue

3

Start / End Page

527 / 538

Location

United States

Related Subject Headings

  • Vaccines, Subunit
  • T-Lymphocytes
  • Neurology & Neurosurgery
  • Lymphopenia
  • Interleukin-2 Receptor alpha Subunit
  • Immunotherapy, Adoptive
  • Immunotherapy
  • Humans
  • Glioma
  • ErbB Receptors
 

Citation

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Chicago
ICMJE
MLA
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Mitchell, D. A., & Sampson, J. H. (2009). Toward effective immunotherapy for the treatment of malignant brain tumors. Neurotherapeutics, 6(3), 527–538. https://doi.org/10.1016/j.nurt.2009.04.003
Mitchell, Duane A., and John H. Sampson. “Toward effective immunotherapy for the treatment of malignant brain tumors.Neurotherapeutics 6, no. 3 (July 2009): 527–38. https://doi.org/10.1016/j.nurt.2009.04.003.
Mitchell DA, Sampson JH. Toward effective immunotherapy for the treatment of malignant brain tumors. Neurotherapeutics. 2009 Jul;6(3):527–38.
Mitchell, Duane A., and John H. Sampson. “Toward effective immunotherapy for the treatment of malignant brain tumors.Neurotherapeutics, vol. 6, no. 3, July 2009, pp. 527–38. Pubmed, doi:10.1016/j.nurt.2009.04.003.
Mitchell DA, Sampson JH. Toward effective immunotherapy for the treatment of malignant brain tumors. Neurotherapeutics. 2009 Jul;6(3):527–538.
Journal cover image

Published In

Neurotherapeutics

DOI

ISSN

1933-7213

Publication Date

July 2009

Volume

6

Issue

3

Start / End Page

527 / 538

Location

United States

Related Subject Headings

  • Vaccines, Subunit
  • T-Lymphocytes
  • Neurology & Neurosurgery
  • Lymphopenia
  • Interleukin-2 Receptor alpha Subunit
  • Immunotherapy, Adoptive
  • Immunotherapy
  • Humans
  • Glioma
  • ErbB Receptors