Mismatch repair in replication fidelity, genetic recombination, and cancer biology.
Publication
, Journal Article
Modrich, P; Lahue, R
Published in: Annu Rev Biochem
1996
Mismatch repair stabilizes the cellular genome by correcting DNA replication errors and by blocking recombination events between divergent DNA sequences. The reaction responsible for strand-specific correction of mispaired bases has been highly conserved during evolution, and homologs of bacterial MutS and MutL, which play key roles in mismatch recognition and initiation of repair, have been identified in yeast and mammalian cells. Inactivation of genes encoding these activities results in a large increase in spontaneous mutability, and in the case of mice and men, predisposition to tumor development.
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Published In
Annu Rev Biochem
DOI
ISSN
0066-4154
Publication Date
1996
Volume
65
Start / End Page
101 / 133
Location
United States
Related Subject Headings
- Recombination, Genetic
- Phenotype
- Nucleic Acid Heteroduplexes
- Neoplasms
- Mitosis
- Humans
- Escherichia coli
- DNA Replication
- DNA Repair
- Biochemistry & Molecular Biology
Citation
APA
Chicago
ICMJE
MLA
NLM
Modrich, P., & Lahue, R. (1996). Mismatch repair in replication fidelity, genetic recombination, and cancer biology. Annu Rev Biochem, 65, 101–133. https://doi.org/10.1146/annurev.bi.65.070196.000533
Modrich, P., and R. Lahue. “Mismatch repair in replication fidelity, genetic recombination, and cancer biology.” Annu Rev Biochem 65 (1996): 101–33. https://doi.org/10.1146/annurev.bi.65.070196.000533.
Modrich P, Lahue R. Mismatch repair in replication fidelity, genetic recombination, and cancer biology. Annu Rev Biochem. 1996;65:101–33.
Modrich, P., and R. Lahue. “Mismatch repair in replication fidelity, genetic recombination, and cancer biology.” Annu Rev Biochem, vol. 65, 1996, pp. 101–33. Pubmed, doi:10.1146/annurev.bi.65.070196.000533.
Modrich P, Lahue R. Mismatch repair in replication fidelity, genetic recombination, and cancer biology. Annu Rev Biochem. 1996;65:101–133.
Published In
Annu Rev Biochem
DOI
ISSN
0066-4154
Publication Date
1996
Volume
65
Start / End Page
101 / 133
Location
United States
Related Subject Headings
- Recombination, Genetic
- Phenotype
- Nucleic Acid Heteroduplexes
- Neoplasms
- Mitosis
- Humans
- Escherichia coli
- DNA Replication
- DNA Repair
- Biochemistry & Molecular Biology