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Effect of rate-dependent left bundle branch block on global and regional left ventricular function.

Publication ,  Journal Article
Bramlet, DA; Morris, KG; Coleman, RE; Albert, D; Cobb, FR
Published in: Circulation
May 1983

Seven subjects with rate-dependent left bundle branch block (RDLBBB) and 13 subjects with normal conduction (control group) underwent upright bicycle exercise radionuclide angiography to determine the effects of the development of RDLBBB on global and regional left ventricular function. Six of the seven subjects with RDLBBB had atypical chest pain syndromes; none had evidence of cardiac disease based on clinical examination and either normal cardiac catheterization or exercise thallium-201 scintigraphy. Radionuclide angiograms were recorded at rest and immediately before and after RDLBBB in the test group, and at rest and during intermediate and maximal exercise in the control group. The development of RDLBBB was associated with an abrupt decrease in left ventricular ejection fraction (LVEF) in six of seven patients (mean decrease 6 +/- 5%) and no overall increase in LVEF between rest and maximal exercise (65 +/- 9% and 65 +/- 12%, respectively). In contrast, LVEF in the control group was 62 +/- 8% at rest and increased to 72 +/- 8% at intermediate and 78 +/- 7% at maximal exercise. The onset of RDLBBB was associated with the development of asynchronous left ventricular contraction in each patient and hypokinesis in four of seven patients. All patients in the control group had normal wall motion at rest and exercise. These data indicate that the development of RDLBBB is associated with changes in global and regional ventricular function that may be confused with development of left ventricular ischemia during exercise.

Duke Scholars

Published In

Circulation

DOI

ISSN

0009-7322

Publication Date

May 1983

Volume

67

Issue

5

Start / End Page

1059 / 1065

Location

United States

Related Subject Headings

  • Thallium
  • Stroke Volume
  • Retrospective Studies
  • Radionuclide Imaging
  • Radioisotopes
  • Prospective Studies
  • Pain
  • Myocardial Contraction
  • Middle Aged
  • Male
 

Citation

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ICMJE
MLA
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Bramlet, D. A., Morris, K. G., Coleman, R. E., Albert, D., & Cobb, F. R. (1983). Effect of rate-dependent left bundle branch block on global and regional left ventricular function. Circulation, 67(5), 1059–1065. https://doi.org/10.1161/01.cir.67.5.1059
Bramlet, D. A., K. G. Morris, R. E. Coleman, D. Albert, and F. R. Cobb. “Effect of rate-dependent left bundle branch block on global and regional left ventricular function.Circulation 67, no. 5 (May 1983): 1059–65. https://doi.org/10.1161/01.cir.67.5.1059.
Bramlet DA, Morris KG, Coleman RE, Albert D, Cobb FR. Effect of rate-dependent left bundle branch block on global and regional left ventricular function. Circulation. 1983 May;67(5):1059–65.
Bramlet, D. A., et al. “Effect of rate-dependent left bundle branch block on global and regional left ventricular function.Circulation, vol. 67, no. 5, May 1983, pp. 1059–65. Pubmed, doi:10.1161/01.cir.67.5.1059.
Bramlet DA, Morris KG, Coleman RE, Albert D, Cobb FR. Effect of rate-dependent left bundle branch block on global and regional left ventricular function. Circulation. 1983 May;67(5):1059–1065.

Published In

Circulation

DOI

ISSN

0009-7322

Publication Date

May 1983

Volume

67

Issue

5

Start / End Page

1059 / 1065

Location

United States

Related Subject Headings

  • Thallium
  • Stroke Volume
  • Retrospective Studies
  • Radionuclide Imaging
  • Radioisotopes
  • Prospective Studies
  • Pain
  • Myocardial Contraction
  • Middle Aged
  • Male