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Direct thrombin inhibitors.

Publication ,  Journal Article
O'Brien, PJ; Mureebe, L
Published in: J Cardiovasc Pharmacol Ther
March 2012

Cardiovascular disease is a leading cause of death and pathologic coagulation plays an integral role in the development, propagation, and intervention of cardiovascular disease. The 2 classic anticoagulants, heparin and vitamin K antagonists, though having served humanity for nearly a century, are both inconvenient and nonspecific. Through both direct and indirect roles, thrombin is essential to coagulation, and makes for a very attractive target in medical intervention of pathologic thrombosis. This article will review the nature of direct thrombin inhibitors, current indications, and ongoing trials.

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Published In

J Cardiovasc Pharmacol Ther

DOI

EISSN

1940-4034

Publication Date

March 2012

Volume

17

Issue

1

Start / End Page

5 / 11

Location

United States

Related Subject Headings

  • Thrombosis
  • Humans
  • Clinical Trials as Topic
  • Cardiovascular System & Hematology
  • Cardiovascular Diseases
  • Blood Coagulation
  • Antithrombins
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
O’Brien, P. J., & Mureebe, L. (2012). Direct thrombin inhibitors. J Cardiovasc Pharmacol Ther, 17(1), 5–11. https://doi.org/10.1177/1074248410395941
O’Brien, P Joshua, and Leila Mureebe. “Direct thrombin inhibitors.J Cardiovasc Pharmacol Ther 17, no. 1 (March 2012): 5–11. https://doi.org/10.1177/1074248410395941.
O’Brien PJ, Mureebe L. Direct thrombin inhibitors. J Cardiovasc Pharmacol Ther. 2012 Mar;17(1):5–11.
O’Brien, P. Joshua, and Leila Mureebe. “Direct thrombin inhibitors.J Cardiovasc Pharmacol Ther, vol. 17, no. 1, Mar. 2012, pp. 5–11. Pubmed, doi:10.1177/1074248410395941.
O’Brien PJ, Mureebe L. Direct thrombin inhibitors. J Cardiovasc Pharmacol Ther. 2012 Mar;17(1):5–11.
Journal cover image

Published In

J Cardiovasc Pharmacol Ther

DOI

EISSN

1940-4034

Publication Date

March 2012

Volume

17

Issue

1

Start / End Page

5 / 11

Location

United States

Related Subject Headings

  • Thrombosis
  • Humans
  • Clinical Trials as Topic
  • Cardiovascular System & Hematology
  • Cardiovascular Diseases
  • Blood Coagulation
  • Antithrombins
  • Animals