
Direct thrombin inhibitors.
Publication
, Journal Article
O'Brien, PJ; Mureebe, L
Published in: J Cardiovasc Pharmacol Ther
March 2012
Cardiovascular disease is a leading cause of death and pathologic coagulation plays an integral role in the development, propagation, and intervention of cardiovascular disease. The 2 classic anticoagulants, heparin and vitamin K antagonists, though having served humanity for nearly a century, are both inconvenient and nonspecific. Through both direct and indirect roles, thrombin is essential to coagulation, and makes for a very attractive target in medical intervention of pathologic thrombosis. This article will review the nature of direct thrombin inhibitors, current indications, and ongoing trials.
Duke Scholars
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Published In
J Cardiovasc Pharmacol Ther
DOI
EISSN
1940-4034
Publication Date
March 2012
Volume
17
Issue
1
Start / End Page
5 / 11
Location
United States
Related Subject Headings
- Thrombosis
- Humans
- Clinical Trials as Topic
- Cardiovascular System & Hematology
- Cardiovascular Diseases
- Blood Coagulation
- Antithrombins
- Animals
- 3214 Pharmacology and pharmaceutical sciences
- 3201 Cardiovascular medicine and haematology
Citation
APA
Chicago
ICMJE
MLA
NLM
O’Brien, P. J., & Mureebe, L. (2012). Direct thrombin inhibitors. J Cardiovasc Pharmacol Ther, 17(1), 5–11. https://doi.org/10.1177/1074248410395941
O’Brien, P Joshua, and Leila Mureebe. “Direct thrombin inhibitors.” J Cardiovasc Pharmacol Ther 17, no. 1 (March 2012): 5–11. https://doi.org/10.1177/1074248410395941.
O’Brien PJ, Mureebe L. Direct thrombin inhibitors. J Cardiovasc Pharmacol Ther. 2012 Mar;17(1):5–11.
O’Brien, P. Joshua, and Leila Mureebe. “Direct thrombin inhibitors.” J Cardiovasc Pharmacol Ther, vol. 17, no. 1, Mar. 2012, pp. 5–11. Pubmed, doi:10.1177/1074248410395941.
O’Brien PJ, Mureebe L. Direct thrombin inhibitors. J Cardiovasc Pharmacol Ther. 2012 Mar;17(1):5–11.

Published In
J Cardiovasc Pharmacol Ther
DOI
EISSN
1940-4034
Publication Date
March 2012
Volume
17
Issue
1
Start / End Page
5 / 11
Location
United States
Related Subject Headings
- Thrombosis
- Humans
- Clinical Trials as Topic
- Cardiovascular System & Hematology
- Cardiovascular Diseases
- Blood Coagulation
- Antithrombins
- Animals
- 3214 Pharmacology and pharmaceutical sciences
- 3201 Cardiovascular medicine and haematology