Hypercoagulable states: a review.
Vascular surgeons are often asked to evaluate patients with recurrent thromboses or thromboses in unusual locations either arterial or venous. There may be obvious inciting factors, but in many of these patients the possibility of a previously undiagnosed hypercoagulable state must be considered. Hypercoagulable states can be acquired (smoking, medication, change in physiologic status as occurs with pregnancy) or congenital. Congenital hypercoagulable disorders are more prevalent in families or patients with a history of thromboembolic events early in life or multiple miscarriages and include conditions such as protein C or S deficiencies, factor V Leiden mutation, and prothrombin gene variant. This article reviews the hypercoagulable states that are encountered in clinical practice as well as guidelines for testing and goals of therapy.
Duke Scholars
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DOI
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Related Subject Headings
- Thrombophilia
- Thrombocytopenia
- Smoking
- Skin
- Pregnancy
- Necrosis
- Humans
- Female
- Contraceptives, Oral
- Cardiovascular System & Hematology
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Thrombophilia
- Thrombocytopenia
- Smoking
- Skin
- Pregnancy
- Necrosis
- Humans
- Female
- Contraceptives, Oral
- Cardiovascular System & Hematology