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Calciphylaxis: a poor prognostic indicator for limb salvage.

Publication ,  Journal Article
Mureebe, L; Moy, M; Balfour, E; Blume, P; Gahtan, V
Published in: J Vasc Surg
June 2001

INTRODUCTION: Calciphylaxis (calcific uremic arteriolopathy) is a rare complication of end-stage renal disease in patients with secondary hyperparathyroidism. Subcutaneous skin nodules and extensive tissue necrosis with vascular calcification characterize this process. DESIGN AND SETTING: The design of the study included case series and literature review. The study was set in a tertiary care hospital. PATIENTS: Four patients presented over an 8-month period with extensive tissue loss and the subsequent diagnosis of calciphylaxis. Two of these patients were revascularized. One underwent primary amputation, and the final patient died before revascularization. The mortality rate for this group was 75%. All patients had significant vascular complications outside the area of initial presentation. CONCLUSIONS: These individuals represent a subset of patients who may not benefit from revascularization or may require extensive regulation of divalent metabolism before consideration for revascularization.

Duke Scholars

Published In

J Vasc Surg

DOI

ISSN

0741-5214

Publication Date

June 2001

Volume

33

Issue

6

Start / End Page

1275 / 1279

Location

United States

Related Subject Headings

  • Wound Healing
  • Salvage Therapy
  • Risk Factors
  • Risk Assessment
  • Prognosis
  • Peripheral Vascular Diseases
  • Middle Aged
  • Male
  • Kidney Failure, Chronic
  • Humans
 

Citation

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Mureebe, L., Moy, M., Balfour, E., Blume, P., & Gahtan, V. (2001). Calciphylaxis: a poor prognostic indicator for limb salvage. J Vasc Surg, 33(6), 1275–1279. https://doi.org/10.1067/mva.2001.115378
Journal cover image

Published In

J Vasc Surg

DOI

ISSN

0741-5214

Publication Date

June 2001

Volume

33

Issue

6

Start / End Page

1275 / 1279

Location

United States

Related Subject Headings

  • Wound Healing
  • Salvage Therapy
  • Risk Factors
  • Risk Assessment
  • Prognosis
  • Peripheral Vascular Diseases
  • Middle Aged
  • Male
  • Kidney Failure, Chronic
  • Humans