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Update on erythrodermic cutaneous T-cell lymphoma: report of the International Society for Cutaneous Lymphomas.

Publication ,  Journal Article
Vonderheid, EC; Bernengo, MG; Burg, G; Duvic, M; Heald, P; Laroche, L; Olsen, E; Pittelkow, M; Russell-Jones, R; Takigawa, M; Willemze, R; ISCL
Published in: J Am Acad Dermatol
January 2002

Two conferences were sponsored by the International Society for Cutaneous Lymphomas (ISCL) to gain consensus on definitions and terminology for clinical use in erythrodermic cutaneous T-cell lymphoma (E-CTCL). Three subsets of E-CTCL were defined: Sézary syndrome ("leukemic phase" E-CTCL), erythrodermic mycosis fungoides (secondary E-CTCL that develops in patients with mycosis fungoides), and E-CTCL, not otherwise defined. The hematologic criteria recommended for Sézary syndrome are intended to identify patients with a worse prognosis compared with the other E-CTCL subsets and consist of one or more of the following: (1) an absolute Sézary cell count of 1000 cells/mm3 or more; (2) a CD4/CD8 ratio of 10 or higher caused by an increase in circulating T cells and/or an aberrant loss or expression of pan-T cell markers by flow cytometry; (3) increased lymphocyte counts with evidence of a T-cell clone in the blood by the Southern blot or polymerase chain reaction technique; or (4) a chromosomally abnormal T-cell clone. For staging purposes, it is proposed that these criteria define the B2 blood rating and that the B2 rating be considered equivalent to nodal involvement.

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Published In

J Am Acad Dermatol

DOI

ISSN

0190-9622

Publication Date

January 2002

Volume

46

Issue

1

Start / End Page

95 / 106

Location

United States

Related Subject Headings

  • Terminology as Topic
  • Societies, Medical
  • Skin Neoplasms
  • Lymphoma, T-Cell, Cutaneous
  • Humans
  • Dermatology & Venereal Diseases
  • Dermatology
  • Dermatitis, Exfoliative
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

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MLA
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Vonderheid, E. C., Bernengo, M. G., Burg, G., Duvic, M., Heald, P., Laroche, L., … ISCL. (2002). Update on erythrodermic cutaneous T-cell lymphoma: report of the International Society for Cutaneous Lymphomas. J Am Acad Dermatol, 46(1), 95–106. https://doi.org/10.1067/mjd.2002.118538
Vonderheid, Eric C., Maria Grazia Bernengo, Günter Burg, Madeleine Duvic, Peter Heald, Liliane Laroche, Elise Olsen, et al. “Update on erythrodermic cutaneous T-cell lymphoma: report of the International Society for Cutaneous Lymphomas.J Am Acad Dermatol 46, no. 1 (January 2002): 95–106. https://doi.org/10.1067/mjd.2002.118538.
Vonderheid EC, Bernengo MG, Burg G, Duvic M, Heald P, Laroche L, et al. Update on erythrodermic cutaneous T-cell lymphoma: report of the International Society for Cutaneous Lymphomas. J Am Acad Dermatol. 2002 Jan;46(1):95–106.
Vonderheid, Eric C., et al. “Update on erythrodermic cutaneous T-cell lymphoma: report of the International Society for Cutaneous Lymphomas.J Am Acad Dermatol, vol. 46, no. 1, Jan. 2002, pp. 95–106. Pubmed, doi:10.1067/mjd.2002.118538.
Vonderheid EC, Bernengo MG, Burg G, Duvic M, Heald P, Laroche L, Olsen E, Pittelkow M, Russell-Jones R, Takigawa M, Willemze R, ISCL. Update on erythrodermic cutaneous T-cell lymphoma: report of the International Society for Cutaneous Lymphomas. J Am Acad Dermatol. 2002 Jan;46(1):95–106.
Journal cover image

Published In

J Am Acad Dermatol

DOI

ISSN

0190-9622

Publication Date

January 2002

Volume

46

Issue

1

Start / End Page

95 / 106

Location

United States

Related Subject Headings

  • Terminology as Topic
  • Societies, Medical
  • Skin Neoplasms
  • Lymphoma, T-Cell, Cutaneous
  • Humans
  • Dermatology & Venereal Diseases
  • Dermatology
  • Dermatitis, Exfoliative
  • 3202 Clinical sciences
  • 1103 Clinical Sciences