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Tretinoin emollient cream for photodamaged skin: results of 48-week, multicenter, double-blind studies.

Publication ,  Journal Article
Olsen, EA; Katz, HI; Levine, N; Nigra, TP; Pochi, PE; Savin, RC; Shupack, J; Weinstein, GD; Lufrano, L; Perry, BH
Published in: J Am Acad Dermatol
August 1997

BACKGROUND: The ability of topical tretinoin to improve certain signs of skin photodamage has been shown previously. OBJECTIVE: Our purpose was to assess the effectiveness of tretinoin emollient cream in maintaining or further improving photodamaged skin during extended use. METHODS: Photodamaged subjects who completed 24 weeks of once-daily use of tretinoin emollient cream 0.05% (n = 149) or 0.01% (n = 149) continued to use the same strength formulation in a 24-week double-blind extension. RESULTS: Maintenance of improvement or continued reduction in signs of photodamage was noted in both investigators' and subjects' evaluations of the 0.05% and 0.01% preparations; these results were confirmed by skin replica analyses. Cutaneous side effects were less common during the extension study than during the first 24 weeks of therapy. CONCLUSION: Both strengths of tretinoin emollient cream (0.05% and 0.01%) appeared safe and effective in the treatment of photodamaged skin during a 48-week treatment period.

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Published In

J Am Acad Dermatol

DOI

ISSN

0190-9622

Publication Date

August 1997

Volume

37

Issue

2 Pt 1

Start / End Page

217 / 226

Location

United States

Related Subject Headings

  • Ultraviolet Rays
  • Tretinoin
  • Skin Aging
  • Skin
  • Ointments
  • Male
  • Keratolytic Agents
  • Humans
  • Female
  • Drug Administration Schedule
 

Citation

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Olsen, E. A., Katz, H. I., Levine, N., Nigra, T. P., Pochi, P. E., Savin, R. C., … Perry, B. H. (1997). Tretinoin emollient cream for photodamaged skin: results of 48-week, multicenter, double-blind studies. J Am Acad Dermatol, 37(2 Pt 1), 217–226. https://doi.org/10.1016/s0190-9622(97)80128-4
Olsen, E. A., H. I. Katz, N. Levine, T. P. Nigra, P. E. Pochi, R. C. Savin, J. Shupack, G. D. Weinstein, L. Lufrano, and B. H. Perry. “Tretinoin emollient cream for photodamaged skin: results of 48-week, multicenter, double-blind studies.J Am Acad Dermatol 37, no. 2 Pt 1 (August 1997): 217–26. https://doi.org/10.1016/s0190-9622(97)80128-4.
Olsen EA, Katz HI, Levine N, Nigra TP, Pochi PE, Savin RC, et al. Tretinoin emollient cream for photodamaged skin: results of 48-week, multicenter, double-blind studies. J Am Acad Dermatol. 1997 Aug;37(2 Pt 1):217–26.
Olsen, E. A., et al. “Tretinoin emollient cream for photodamaged skin: results of 48-week, multicenter, double-blind studies.J Am Acad Dermatol, vol. 37, no. 2 Pt 1, Aug. 1997, pp. 217–26. Pubmed, doi:10.1016/s0190-9622(97)80128-4.
Olsen EA, Katz HI, Levine N, Nigra TP, Pochi PE, Savin RC, Shupack J, Weinstein GD, Lufrano L, Perry BH. Tretinoin emollient cream for photodamaged skin: results of 48-week, multicenter, double-blind studies. J Am Acad Dermatol. 1997 Aug;37(2 Pt 1):217–226.
Journal cover image

Published In

J Am Acad Dermatol

DOI

ISSN

0190-9622

Publication Date

August 1997

Volume

37

Issue

2 Pt 1

Start / End Page

217 / 226

Location

United States

Related Subject Headings

  • Ultraviolet Rays
  • Tretinoin
  • Skin Aging
  • Skin
  • Ointments
  • Male
  • Keratolytic Agents
  • Humans
  • Female
  • Drug Administration Schedule