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Clinical and laboratory diagnosis of von Willebrand disease: a synopsis of the 2008 NHLBI/NIH guidelines.

Publication ,  Journal Article
Nichols, WL; Rick, ME; Ortel, TL; Montgomery, RR; Sadler, JE; Yawn, BP; James, AH; Hultin, MB; Manco-Johnson, MJ; Weinstein, M
Published in: Am J Hematol
June 2009

Von Willebrand factor (VWF) mediates blood platelet adhesion and accumulation at sites of blood vessel injury, and also carries coagulation factor VIII (FVIII) that is important for generating procoagulant activity. Von Willebrand disease (VWD), the most common inherited bleeding disorder, affects males and females, and reflects deficiency or defects of VWF that may also cause decreased FVIII. It may also occur less commonly as an acquired disorder (acquired von Willebrand syndrome). This article briefly summarizes selected features of the March 2008 evidence-based clinical and laboratory diagnostic recommendations from the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel for assessment for VWD or other bleeding disorders or risks. Management of VWD is also addressed in the NHLBI guidelines, but is not summarized here. The VWD guidelines are available at the NHLBI Web site (http://www.nhlbi.nih.gov/guidelines/vwd).

Duke Scholars

Published In

Am J Hematol

DOI

EISSN

1096-8652

Publication Date

June 2009

Volume

84

Issue

6

Start / End Page

366 / 370

Location

United States

Related Subject Headings

  • von Willebrand Diseases
  • United States
  • National Institutes of Health (U.S.)
  • Immunology
  • Humans
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Nichols, W. L., Rick, M. E., Ortel, T. L., Montgomery, R. R., Sadler, J. E., Yawn, B. P., … Weinstein, M. (2009). Clinical and laboratory diagnosis of von Willebrand disease: a synopsis of the 2008 NHLBI/NIH guidelines. Am J Hematol, 84(6), 366–370. https://doi.org/10.1002/ajh.21405
Nichols, William L., Margaret E. Rick, Thomas L. Ortel, Robert R. Montgomery, J Evan Sadler, Barbara P. Yawn, Andra H. James, Mae B. Hultin, Marilyn J. Manco-Johnson, and Mark Weinstein. “Clinical and laboratory diagnosis of von Willebrand disease: a synopsis of the 2008 NHLBI/NIH guidelines.Am J Hematol 84, no. 6 (June 2009): 366–70. https://doi.org/10.1002/ajh.21405.
Nichols WL, Rick ME, Ortel TL, Montgomery RR, Sadler JE, Yawn BP, et al. Clinical and laboratory diagnosis of von Willebrand disease: a synopsis of the 2008 NHLBI/NIH guidelines. Am J Hematol. 2009 Jun;84(6):366–70.
Nichols, William L., et al. “Clinical and laboratory diagnosis of von Willebrand disease: a synopsis of the 2008 NHLBI/NIH guidelines.Am J Hematol, vol. 84, no. 6, June 2009, pp. 366–70. Pubmed, doi:10.1002/ajh.21405.
Nichols WL, Rick ME, Ortel TL, Montgomery RR, Sadler JE, Yawn BP, James AH, Hultin MB, Manco-Johnson MJ, Weinstein M. Clinical and laboratory diagnosis of von Willebrand disease: a synopsis of the 2008 NHLBI/NIH guidelines. Am J Hematol. 2009 Jun;84(6):366–370.
Journal cover image

Published In

Am J Hematol

DOI

EISSN

1096-8652

Publication Date

June 2009

Volume

84

Issue

6

Start / End Page

366 / 370

Location

United States

Related Subject Headings

  • von Willebrand Diseases
  • United States
  • National Institutes of Health (U.S.)
  • Immunology
  • Humans
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology