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Viral clearance is associated with improved insulin resistance in genotype 1 chronic hepatitis C but not genotype 2/3.

Publication ,  Journal Article
Thompson, AJ; Patel, K; Chuang, W-L; Lawitz, EJ; Rodriguez-Torres, M; Rustgi, VK; Flisiak, R; Pianko, S; Diago, M; Arora, S; Foster, GR ...
Published in: Gut
January 2012

OBJECTIVES: Genotype-specific associations between hepatitis C virus (HCV) and insulin resistance (IR) have been described, but a causal relationship remains unclear. This study investigated the association between a sustained virological response (SVR) and IR after chronic HCV therapy. METHODS: 2255 treatment-naive patients with chronic HCV genotype 1 or 2/3 were enrolled in two phase 3 trials of albinterferon alpha-2b versus pegylated interferon alpha-2a for 48 or 24 weeks, respectively. IR was measured before treatment and 12 weeks after treatment using homeostasis model assessment (HOMA)-IR. RESULTS: Paired HOMA-IR measurements were available in 1038 non-diabetic patients (497 with genotype 1; 541 with genotype 2/3). At baseline the prevalence of HOMA-IR >3 was greater in patients with genotype 1 than 2/3 (33% vs 27%; p=0.048). There was a significant reduction in the prevalence of IR in patients with genotype 1 achieving SVR (δ 10%; p<0.001), but not in genotype 1 non-responders or those with genotype 2/3. Multivariate analysis indicated that SVR was associated with a significant reduction in mean HOMA-IR in patients with genotype 1 (p=0.004), but not in those with genotype 2/3, which was independent of body mass index, alanine transaminase, γ-glutamyl transpeptidase and lipid level changes. CONCLUSIONS: SVR is associated with a reduction in HOMA-IR in patients with HCV genotype 1 but not in those with genotype 2/3. Genotype 1 may have a direct effect on the development of IR, independent of host metabolic factors, and may be partially reversed by viral eradication.

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Published In

Gut

DOI

EISSN

1468-3288

Publication Date

January 2012

Volume

61

Issue

1

Start / End Page

128 / 134

Location

England

Related Subject Headings

  • Viral Load
  • Treatment Outcome
  • Recombinant Proteins
  • Polyethylene Glycols
  • Multivariate Analysis
  • Male
  • Logistic Models
  • Linear Models
  • Interferon-alpha
  • Insulin Resistance
 

Citation

APA
Chicago
ICMJE
MLA
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Thompson, A. J., Patel, K., Chuang, W.-L., Lawitz, E. J., Rodriguez-Torres, M., Rustgi, V. K., … ACHIEVE-1 and ACHIEVE-2/3 Study Teams. (2012). Viral clearance is associated with improved insulin resistance in genotype 1 chronic hepatitis C but not genotype 2/3. Gut, 61(1), 128–134. https://doi.org/10.1136/gut.2010.236158
Thompson, Alexander J., Keyur Patel, Wan-Long Chuang, Eric J. Lawitz, Maribel Rodriguez-Torres, Vinod K. Rustgi, Robert Flisiak, et al. “Viral clearance is associated with improved insulin resistance in genotype 1 chronic hepatitis C but not genotype 2/3.Gut 61, no. 1 (January 2012): 128–34. https://doi.org/10.1136/gut.2010.236158.
Thompson AJ, Patel K, Chuang W-L, Lawitz EJ, Rodriguez-Torres M, Rustgi VK, et al. Viral clearance is associated with improved insulin resistance in genotype 1 chronic hepatitis C but not genotype 2/3. Gut. 2012 Jan;61(1):128–34.
Thompson, Alexander J., et al. “Viral clearance is associated with improved insulin resistance in genotype 1 chronic hepatitis C but not genotype 2/3.Gut, vol. 61, no. 1, Jan. 2012, pp. 128–34. Pubmed, doi:10.1136/gut.2010.236158.
Thompson AJ, Patel K, Chuang W-L, Lawitz EJ, Rodriguez-Torres M, Rustgi VK, Flisiak R, Pianko S, Diago M, Arora S, Foster GR, Torbenson M, Benhamou Y, Nelson DR, Sulkowski MS, Zeuzem S, Pulkstenis E, Subramanian GM, McHutchison JG, ACHIEVE-1 and ACHIEVE-2/3 Study Teams. Viral clearance is associated with improved insulin resistance in genotype 1 chronic hepatitis C but not genotype 2/3. Gut. 2012 Jan;61(1):128–134.

Published In

Gut

DOI

EISSN

1468-3288

Publication Date

January 2012

Volume

61

Issue

1

Start / End Page

128 / 134

Location

England

Related Subject Headings

  • Viral Load
  • Treatment Outcome
  • Recombinant Proteins
  • Polyethylene Glycols
  • Multivariate Analysis
  • Male
  • Logistic Models
  • Linear Models
  • Interferon-alpha
  • Insulin Resistance