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Stabilization of microsatellite sequences by variant repeats in the yeast Saccharomyces cerevisiae.

Publication ,  Journal Article
Petes, TD; Greenwell, PW; Dominska, M
Published in: Genetics
June 1997

We examined the effect of a single variant repeat on the stability of a 51-base pair (bp) microsatellite (poly GT). We found that the insertion stabilizes the microsatellite about fivefold in wild-type strains. The stabilizing effect of the variant base was also observed in strains with mutations in the DNA mismatch repair genes pms1, msh2 and msh3, indicating that this effect does not require a functional DNA mismatch repair system. Most of the microsatellite alterations in the pms1, msh2 and msh3 strains were additions or deletions of single GT repeats, but about half of the alterations in the wild-type and msh6 strains were large (> 8 bp) deletions or additions.

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Published In

Genetics

DOI

ISSN

0016-6731

Publication Date

June 1997

Volume

146

Issue

2

Start / End Page

491 / 498

Location

United States

Related Subject Headings

  • Sequence Deletion
  • Sequence Analysis, DNA
  • Saccharomyces cerevisiae
  • Polydeoxyribonucleotides
  • Plasmids
  • Mutation
  • Molecular Sequence Data
  • Microsatellite Repeats
  • Developmental Biology
  • DNA-Directed DNA Polymerase
 

Citation

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Petes, T. D., Greenwell, P. W., & Dominska, M. (1997). Stabilization of microsatellite sequences by variant repeats in the yeast Saccharomyces cerevisiae. Genetics, 146(2), 491–498. https://doi.org/10.1093/genetics/146.2.491
Petes, T. D., P. W. Greenwell, and M. Dominska. “Stabilization of microsatellite sequences by variant repeats in the yeast Saccharomyces cerevisiae.Genetics 146, no. 2 (June 1997): 491–98. https://doi.org/10.1093/genetics/146.2.491.
Petes TD, Greenwell PW, Dominska M. Stabilization of microsatellite sequences by variant repeats in the yeast Saccharomyces cerevisiae. Genetics. 1997 Jun;146(2):491–8.
Petes, T. D., et al. “Stabilization of microsatellite sequences by variant repeats in the yeast Saccharomyces cerevisiae.Genetics, vol. 146, no. 2, June 1997, pp. 491–98. Pubmed, doi:10.1093/genetics/146.2.491.
Petes TD, Greenwell PW, Dominska M. Stabilization of microsatellite sequences by variant repeats in the yeast Saccharomyces cerevisiae. Genetics. 1997 Jun;146(2):491–498.

Published In

Genetics

DOI

ISSN

0016-6731

Publication Date

June 1997

Volume

146

Issue

2

Start / End Page

491 / 498

Location

United States

Related Subject Headings

  • Sequence Deletion
  • Sequence Analysis, DNA
  • Saccharomyces cerevisiae
  • Polydeoxyribonucleotides
  • Plasmids
  • Mutation
  • Molecular Sequence Data
  • Microsatellite Repeats
  • Developmental Biology
  • DNA-Directed DNA Polymerase