DNA-binding protein RAP1 stimulates meiotic recombination at the HIS4 locus in yeast.
Publication
, Journal Article
White, MA; Wierdl, M; Detloff, P; Petes, TD
Published in: Proc Natl Acad Sci U S A
November 1, 1991
In the yeast Saccharomyces cerevisiae, as in other eukaryotes, some regions of the genome have a much higher rate of meiotic recombination than others. We show below that the binding of the RAP1 protein to a site upstream of the HIS4 gene is necessary for a high rate of meiotic (but not mitotic) recombination at this locus. A mutation in the RAP1 binding site at HIS4 results in a decrease in recombination; overproduction of RAP1 causes an increase in recombination at HIS4 above wild-type levels.
Duke Scholars
Published In
Proc Natl Acad Sci U S A
DOI
ISSN
0027-8424
Publication Date
November 1, 1991
Volume
88
Issue
21
Start / End Page
9755 / 9759
Location
United States
Related Subject Headings
- rap GTP-Binding Proteins
- Saccharomyces cerevisiae
- Regulatory Sequences, Nucleic Acid
- Recombination, Genetic
- Oligonucleotides
- Molecular Sequence Data
- Mitosis
- Meiosis
- Histidine
- Genes, Fungal
Citation
APA
Chicago
ICMJE
MLA
NLM
White, M. A., Wierdl, M., Detloff, P., & Petes, T. D. (1991). DNA-binding protein RAP1 stimulates meiotic recombination at the HIS4 locus in yeast. Proc Natl Acad Sci U S A, 88(21), 9755–9759. https://doi.org/10.1073/pnas.88.21.9755
White, M. A., M. Wierdl, P. Detloff, and T. D. Petes. “DNA-binding protein RAP1 stimulates meiotic recombination at the HIS4 locus in yeast.” Proc Natl Acad Sci U S A 88, no. 21 (November 1, 1991): 9755–59. https://doi.org/10.1073/pnas.88.21.9755.
White MA, Wierdl M, Detloff P, Petes TD. DNA-binding protein RAP1 stimulates meiotic recombination at the HIS4 locus in yeast. Proc Natl Acad Sci U S A. 1991 Nov 1;88(21):9755–9.
White, M. A., et al. “DNA-binding protein RAP1 stimulates meiotic recombination at the HIS4 locus in yeast.” Proc Natl Acad Sci U S A, vol. 88, no. 21, Nov. 1991, pp. 9755–59. Pubmed, doi:10.1073/pnas.88.21.9755.
White MA, Wierdl M, Detloff P, Petes TD. DNA-binding protein RAP1 stimulates meiotic recombination at the HIS4 locus in yeast. Proc Natl Acad Sci U S A. 1991 Nov 1;88(21):9755–9759.
Published In
Proc Natl Acad Sci U S A
DOI
ISSN
0027-8424
Publication Date
November 1, 1991
Volume
88
Issue
21
Start / End Page
9755 / 9759
Location
United States
Related Subject Headings
- rap GTP-Binding Proteins
- Saccharomyces cerevisiae
- Regulatory Sequences, Nucleic Acid
- Recombination, Genetic
- Oligonucleotides
- Molecular Sequence Data
- Mitosis
- Meiosis
- Histidine
- Genes, Fungal