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Identification of yeast mutants with altered telomere structure.

Publication ,  Journal Article
Lustig, AJ; Petes, TD
Published in: Proc Natl Acad Sci U S A
March 1986

The chromosomes of the yeast Saccharomyces cerevisiae terminate in a tract of simple-sequence DNA [poly(C1-3A)] that is several hundred base pairs long. We describe the identification of mutant yeast strains that have telomeric tracts that are shorter than normal. A genetic analysis of these strains indicates that these short telomeres are the result of single nuclear recessive mutations and that these mutations can be classified into two different complementation groups. The full expression of the mutant phenotype shows a very long lag (approximately equal to 150 cell divisions). From our analysis of these mutants as well as other data, we suggest that the duplication of the telomeric poly(C1-3A) tract involves two processes, semiconservative replication and untemplated terminal addition of nucleotides.

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Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

March 1986

Volume

83

Issue

5

Start / End Page

1398 / 1402

Location

United States

Related Subject Headings

  • Saccharomyces cerevisiae Proteins
  • Saccharomyces cerevisiae
  • Repetitive Sequences, Nucleic Acid
  • Protein Serine-Threonine Kinases
  • Phenotype
  • Mutation
  • Intracellular Signaling Peptides and Proteins
  • Genes, Recessive
  • Fungal Proteins
  • DNA, Fungal
 

Citation

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Lustig, A. J., & Petes, T. D. (1986). Identification of yeast mutants with altered telomere structure. Proc Natl Acad Sci U S A, 83(5), 1398–1402. https://doi.org/10.1073/pnas.83.5.1398
Lustig, A. J., and T. D. Petes. “Identification of yeast mutants with altered telomere structure.Proc Natl Acad Sci U S A 83, no. 5 (March 1986): 1398–1402. https://doi.org/10.1073/pnas.83.5.1398.
Lustig AJ, Petes TD. Identification of yeast mutants with altered telomere structure. Proc Natl Acad Sci U S A. 1986 Mar;83(5):1398–402.
Lustig, A. J., and T. D. Petes. “Identification of yeast mutants with altered telomere structure.Proc Natl Acad Sci U S A, vol. 83, no. 5, Mar. 1986, pp. 1398–402. Pubmed, doi:10.1073/pnas.83.5.1398.
Lustig AJ, Petes TD. Identification of yeast mutants with altered telomere structure. Proc Natl Acad Sci U S A. 1986 Mar;83(5):1398–1402.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

March 1986

Volume

83

Issue

5

Start / End Page

1398 / 1402

Location

United States

Related Subject Headings

  • Saccharomyces cerevisiae Proteins
  • Saccharomyces cerevisiae
  • Repetitive Sequences, Nucleic Acid
  • Protein Serine-Threonine Kinases
  • Phenotype
  • Mutation
  • Intracellular Signaling Peptides and Proteins
  • Genes, Recessive
  • Fungal Proteins
  • DNA, Fungal