Local administration of L-703,081 using a composite polymeric stent reduces platelet deposition in canine coronary arteries.
Publication
, Journal Article
Santos, RM; Tanguay, JF; Crowley, JJ; Kruse, KR; Sanders-Millare, D; Zidar, JP; Phillips, HR; Merhi, Y; Garcia-Cantu, E; Bonan, R; Côté, G; Stack, RS
Published in: Am J Cardiol
September 1, 1998
We compared the effect on platelet deposition of the glycoprotein IIb/IIIa receptor antagonist L-703,081, administered locally via a drug delivery stent, with that of a standard metal stent in a canine coronary model. There was a significant reduction in platelet deposition using the L-703,081-impregnated stent compared with the bare metal stent. This study demonstrates an alternative route of delivery of GPIIb/IIIa antagonists with potential advantages over systemic administration.
Duke Scholars
Published In
Am J Cardiol
DOI
ISSN
0002-9149
Publication Date
September 1, 1998
Volume
82
Issue
5
Start / End Page
673 / A8
Location
United States
Related Subject Headings
- Surface Properties
- Structure-Activity Relationship
- Stents
- Polyesters
- Platelet Glycoprotein GPIIb-IIIa Complex
- Platelet Aggregation Inhibitors
- Platelet Aggregation
- Equipment Design
- Drug Implants
- Dogs
Citation
APA
Chicago
ICMJE
MLA
NLM
Santos, R. M., Tanguay, J. F., Crowley, J. J., Kruse, K. R., Sanders-Millare, D., Zidar, J. P., … Stack, R. S. (1998). Local administration of L-703,081 using a composite polymeric stent reduces platelet deposition in canine coronary arteries. Am J Cardiol, 82(5), 673-A8. https://doi.org/10.1016/s0002-9149(98)00418-4
Santos, R. M., J. F. Tanguay, J. J. Crowley, K. R. Kruse, D. Sanders-Millare, J. P. Zidar, H. R. Phillips, et al. “Local administration of L-703,081 using a composite polymeric stent reduces platelet deposition in canine coronary arteries.” Am J Cardiol 82, no. 5 (September 1, 1998): 673-A8. https://doi.org/10.1016/s0002-9149(98)00418-4.
Santos RM, Tanguay JF, Crowley JJ, Kruse KR, Sanders-Millare D, Zidar JP, et al. Local administration of L-703,081 using a composite polymeric stent reduces platelet deposition in canine coronary arteries. Am J Cardiol. 1998 Sep 1;82(5):673-A8.
Santos, R. M., et al. “Local administration of L-703,081 using a composite polymeric stent reduces platelet deposition in canine coronary arteries.” Am J Cardiol, vol. 82, no. 5, Sept. 1998, pp. 673-A8. Pubmed, doi:10.1016/s0002-9149(98)00418-4.
Santos RM, Tanguay JF, Crowley JJ, Kruse KR, Sanders-Millare D, Zidar JP, Phillips HR, Merhi Y, Garcia-Cantu E, Bonan R, Côté G, Stack RS. Local administration of L-703,081 using a composite polymeric stent reduces platelet deposition in canine coronary arteries. Am J Cardiol. 1998 Sep 1;82(5):673-A8.
Published In
Am J Cardiol
DOI
ISSN
0002-9149
Publication Date
September 1, 1998
Volume
82
Issue
5
Start / End Page
673 / A8
Location
United States
Related Subject Headings
- Surface Properties
- Structure-Activity Relationship
- Stents
- Polyesters
- Platelet Glycoprotein GPIIb-IIIa Complex
- Platelet Aggregation Inhibitors
- Platelet Aggregation
- Equipment Design
- Drug Implants
- Dogs