
A case of delirium, motor disturbances, and autonomic dysfunction due to baclofen and tizanidine withdrawal: a review of the literature.
Publication
, Journal Article
Karol, DE; Muzyk, AJ; Preud'homme, XA
Published in: Gen Hosp Psychiatry
2011
We report a case of delirium accompanied by extrapyramidal symptoms and autonomic dysfunction in a 59-year-old man following abrupt cessation of baclofen and tizanidine. An extensive search for the etiology was undertaken, but it was only after a careful history was taken that suspicion for baclofen and tizanidine withdrawal was raised. The delirium and motor disturbances resolved within 24 h of reintroduction of baclofen. Withdrawal from muscle relaxants requires a high index of suspicion but should be considered in patients who manifest signs and symptoms of withdrawal from the medications, particularly visual hallucinations, rigidity and autonomic dysfunction.
Duke Scholars
Published In
Gen Hosp Psychiatry
DOI
EISSN
1873-7714
Publication Date
2011
Volume
33
Issue
1
Start / End Page
84.e1 / 84.e2
Location
United States
Related Subject Headings
- Substance Withdrawal Syndrome
- Psychiatry
- Middle Aged
- Male
- Humans
- Delirium
- Clonidine
- Baclofen
- Autonomic Nervous System Diseases
- Anticonvulsants
Citation
APA
Chicago
ICMJE
MLA
NLM
Karol, D. E., Muzyk, A. J., & Preud’homme, X. A. (2011). A case of delirium, motor disturbances, and autonomic dysfunction due to baclofen and tizanidine withdrawal: a review of the literature. Gen Hosp Psychiatry, 33(1), 84.e1-84.e2. https://doi.org/10.1016/j.genhosppsych.2010.10.003
Karol, David E., Andrew J. Muzyk, and Xavier A. Preud’homme. “A case of delirium, motor disturbances, and autonomic dysfunction due to baclofen and tizanidine withdrawal: a review of the literature.” Gen Hosp Psychiatry 33, no. 1 (2011): 84.e1-84.e2. https://doi.org/10.1016/j.genhosppsych.2010.10.003.
Karol DE, Muzyk AJ, Preud’homme XA. A case of delirium, motor disturbances, and autonomic dysfunction due to baclofen and tizanidine withdrawal: a review of the literature. Gen Hosp Psychiatry. 2011;33(1):84.e1-84.e2.
Karol, David E., et al. “A case of delirium, motor disturbances, and autonomic dysfunction due to baclofen and tizanidine withdrawal: a review of the literature.” Gen Hosp Psychiatry, vol. 33, no. 1, 2011, pp. 84.e1-84.e2. Pubmed, doi:10.1016/j.genhosppsych.2010.10.003.
Karol DE, Muzyk AJ, Preud’homme XA. A case of delirium, motor disturbances, and autonomic dysfunction due to baclofen and tizanidine withdrawal: a review of the literature. Gen Hosp Psychiatry. 2011;33(1):84.e1-84.e2.

Published In
Gen Hosp Psychiatry
DOI
EISSN
1873-7714
Publication Date
2011
Volume
33
Issue
1
Start / End Page
84.e1 / 84.e2
Location
United States
Related Subject Headings
- Substance Withdrawal Syndrome
- Psychiatry
- Middle Aged
- Male
- Humans
- Delirium
- Clonidine
- Baclofen
- Autonomic Nervous System Diseases
- Anticonvulsants