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Regulation of cerebral glucose metabolism.

Publication ,  Journal Article
Rao, J; Oz, G; Seaquist, ER
Published in: Minerva Endocrinol
June 2006

The brain uses glucose as a primary fuel for energy generation. Glucose gains entry into the brain by facilitated diffusion across the blood-brain barrier. Glucose transport may adapt during changes in cerebral glucose metabolism, neural activation and changes in plasma glucose levels. Within the brain, glucose is either oxidized to produce ATP or used to synthesize glycogen. To ensure the delivery of a continuous supply of glucose to maintain normal cellular function, the brain has developed a complex regulatory system to preserve its supply. Gluco-sensing neurons have been demonstrated in various regions of the brain and they appear to play an important role in not only detecting changes in brain glucose levels but also in initiating responses to maintain constant brain glucose levels. In this review, we will discuss the regulation of brain glucose metabolism (CMR(gluc)) and how it adapts to chronic changes in glycemia, like that seen in hyperglycemic patients with diabetes mellitus or patients with type 1 diabetes, recurrent hypoglycemia, and hypoglycemia unawareness. We will also consider the role of brain glycogen in providing fuel for energy under conditions of stress.

Duke Scholars

Published In

Minerva Endocrinol

ISSN

0391-1977

Publication Date

June 2006

Volume

31

Issue

2

Start / End Page

149 / 158

Location

Italy

Related Subject Headings

  • Neurons
  • Neuroglia
  • Insulin
  • Humans
  • Glycogen
  • Glucose Transporter Type 3
  • Glucose Transporter Type 1
  • Glucose
  • Diabetes Mellitus, Type 2
  • Diabetes Mellitus, Type 1
 

Citation

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Chicago
ICMJE
MLA
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Rao, J., Oz, G., & Seaquist, E. R. (2006). Regulation of cerebral glucose metabolism. Minerva Endocrinol, 31(2), 149–158.
Rao, J., G. Oz, and E. R. Seaquist. “Regulation of cerebral glucose metabolism.Minerva Endocrinol 31, no. 2 (June 2006): 149–58.
Rao J, Oz G, Seaquist ER. Regulation of cerebral glucose metabolism. Minerva Endocrinol. 2006 Jun;31(2):149–58.
Rao, J., et al. “Regulation of cerebral glucose metabolism.Minerva Endocrinol, vol. 31, no. 2, June 2006, pp. 149–58.
Rao J, Oz G, Seaquist ER. Regulation of cerebral glucose metabolism. Minerva Endocrinol. 2006 Jun;31(2):149–158.

Published In

Minerva Endocrinol

ISSN

0391-1977

Publication Date

June 2006

Volume

31

Issue

2

Start / End Page

149 / 158

Location

Italy

Related Subject Headings

  • Neurons
  • Neuroglia
  • Insulin
  • Humans
  • Glycogen
  • Glucose Transporter Type 3
  • Glucose Transporter Type 1
  • Glucose
  • Diabetes Mellitus, Type 2
  • Diabetes Mellitus, Type 1