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A model for the computation and encoding of azimuthal information by the lateral superior olive.

Publication ,  Journal Article
Reed, MC; Blum, JJ
Published in: The Journal of the Acoustical Society of America
September 1990

A structural model is proposed for the processing of interaural intensity differences by the lateral superior olive. One fundamental assumption is that the incoming excitatory projections from the ipsilateral anteroventral cochlear nucleus innervate columns of LSO neurons serially according to threshold. A second fundamental assumption is that the inhibitory innervation from the ipsilateral medial nucleus of the trapezoid body is also serially arranged according to threshold but in the opposite direction along the LSO column. Using neurophysiological and neuroanatomical data for neuronal response curves, connectional patterns, and cell and synapse numbers, the model was formulated quantitatively and implemented for machine computation. Azimuthal location is encoded by the position along the LSO column where LSO cell firing first goes to zero. Accuracy of coding was tested for three different connectional schemes, for variations in neuronal parameters, and for cell and synapse death. Encoding is shown to be independent of absolute sound level and to vary linearly with interaural intensity difference.

Duke Scholars

Published In

The Journal of the Acoustical Society of America

DOI

EISSN

1520-8524

ISSN

0001-4966

Publication Date

September 1990

Volume

88

Issue

3

Start / End Page

1442 / 1453

Related Subject Headings

  • Synapses
  • Sound Localization
  • Olivary Nucleus
  • Neurons
  • Nerve Fibers
  • Nerve Degeneration
  • Models, Neurological
  • Humans
  • Dominance, Cerebral
  • Cochlear Nerve
 

Citation

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Reed, M. C., & Blum, J. J. (1990). A model for the computation and encoding of azimuthal information by the lateral superior olive. The Journal of the Acoustical Society of America, 88(3), 1442–1453. https://doi.org/10.1121/1.399721
Reed, M. C., and J. J. Blum. “A model for the computation and encoding of azimuthal information by the lateral superior olive.The Journal of the Acoustical Society of America 88, no. 3 (September 1990): 1442–53. https://doi.org/10.1121/1.399721.
Reed MC, Blum JJ. A model for the computation and encoding of azimuthal information by the lateral superior olive. The Journal of the Acoustical Society of America. 1990 Sep;88(3):1442–53.
Reed, M. C., and J. J. Blum. “A model for the computation and encoding of azimuthal information by the lateral superior olive.The Journal of the Acoustical Society of America, vol. 88, no. 3, Sept. 1990, pp. 1442–53. Epmc, doi:10.1121/1.399721.
Reed MC, Blum JJ. A model for the computation and encoding of azimuthal information by the lateral superior olive. The Journal of the Acoustical Society of America. 1990 Sep;88(3):1442–1453.

Published In

The Journal of the Acoustical Society of America

DOI

EISSN

1520-8524

ISSN

0001-4966

Publication Date

September 1990

Volume

88

Issue

3

Start / End Page

1442 / 1453

Related Subject Headings

  • Synapses
  • Sound Localization
  • Olivary Nucleus
  • Neurons
  • Nerve Fibers
  • Nerve Degeneration
  • Models, Neurological
  • Humans
  • Dominance, Cerebral
  • Cochlear Nerve