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The gelatinous bone marrow (serous atrophy) in patients with acquired immunodeficiency syndrome. Evidence of excess sulfated glycosaminoglycan.

Publication ,  Journal Article
Mehta, K; Gascon, P; Robboy, S
Published in: Arch Pathol Lab Med
May 1992

Patients with the acquired immunodeficiency syndrome uniformly exhibit hematologic abnormalities characterized by anemia and/or pancytopenia. In a study of 75 consecutive bone marrow biopsy specimens from patients with acquired immunodeficiency syndrome, 29% exhibited serous atrophy, characterized by marrow hypoplasia, fat atrophy, and deposition of extracellular "gelatinous" material (gelatinous transformation). The latter material was composed exclusively of glycosaminoglycans (alcian blue positive at pHs of 2.5 and 1.0, and sensitive to testicular hyaluronidase digestion). Excess glycosaminoglycan, which significantly alters the bone marrow microenvironment, is detrimental to erythropoiesis. The present findings support the concept that the damaged hematopoietic inductive microenvironment in patients with acquired immunodeficiency syndrome leads to failure of hematopoiesis, and, hence, to peripheral hematologic abnormalities.

Duke Scholars

Published In

Arch Pathol Lab Med

ISSN

0003-9985

Publication Date

May 1992

Volume

116

Issue

5

Start / End Page

504 / 508

Location

United States

Related Subject Headings

  • Pathology
  • Male
  • Humans
  • HIV Seropositivity
  • Granuloma
  • Glycosaminoglycans
  • Female
  • Bone Marrow Diseases
  • Bone Marrow
  • Adult
 

Published In

Arch Pathol Lab Med

ISSN

0003-9985

Publication Date

May 1992

Volume

116

Issue

5

Start / End Page

504 / 508

Location

United States

Related Subject Headings

  • Pathology
  • Male
  • Humans
  • HIV Seropositivity
  • Granuloma
  • Glycosaminoglycans
  • Female
  • Bone Marrow Diseases
  • Bone Marrow
  • Adult