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Application of novel response/progression measures for surgically delivered therapies for gliomas: Response Assessment in Neuro-Oncology (RANO) Working Group.

Publication ,  Journal Article
Vogelbaum, MA; Jost, S; Aghi, MK; Heimberger, AB; Sampson, JH; Wen, PY; Macdonald, DR; Van den Bent, MJ; Chang, SM
Published in: Neurosurgery
January 2012

BACKGROUND: The Response Assessment in Neuro-Oncology (RANO) Working Group is an international, multidisciplinary effort to develop new standardized response criteria for clinical trials in brain tumors. The RANO group identified knowledge gaps relating to the definitions of tumor response and progression after the use of surgical or surgically based treatments. OBJECTIVE: To outline a proposal for new response and progression criteria for the assessment of the effects of surgery and surgically delivered therapies for patients with gliomas. METHODS: The Surgery Working Group of RANO identified surgically related end-point evaluation problems that were not addressed in the original Macdonald criteria, performed an extensive literature review, and used a consensus-building process to develop recommendations for how to address these issues in the setting of clinical trials. RESULTS: Recommendations were formulated for surgically related issues, including imaging changes associated with surgical resection or surgically mediated adjuvant local therapies, the determination of progression in the setting where all enhancing tumor has been removed, and how new enhancement should be interpreted in the setting where local therapies that are known to produce nonspecific enhancement have been used. Additionally, the terminology used to describe the completeness of surgical resections has been recognized to be inconsistently applied to enhancing vs nonenhancing tumors, and a new set of descriptors is proposed. CONCLUSION: The RANO process is intended to produce end-point criteria for clinical trials that take into account the effects of prior and ongoing therapies. The RANO criteria will continue to evolve as new therapies and technologies are introduced into clinical trial and/or practice.

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Published In

Neurosurgery

DOI

EISSN

1524-4040

Publication Date

January 2012

Volume

70

Issue

1

Start / End Page

234 / 243

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Practice Guidelines as Topic
  • Neurology & Neurosurgery
  • Neoplasm Recurrence, Local
  • Magnetic Resonance Imaging
  • International Cooperation
  • Humans
  • Glioma
  • Combined Modality Therapy
  • Brain Neoplasms
 

Citation

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ICMJE
MLA
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Vogelbaum, M. A., Jost, S., Aghi, M. K., Heimberger, A. B., Sampson, J. H., Wen, P. Y., … Chang, S. M. (2012). Application of novel response/progression measures for surgically delivered therapies for gliomas: Response Assessment in Neuro-Oncology (RANO) Working Group. Neurosurgery, 70(1), 234–243. https://doi.org/10.1227/NEU.0b013e318223f5a7
Vogelbaum, Michael A., Sarah Jost, Manish K. Aghi, Amy B. Heimberger, John H. Sampson, Patrick Y. Wen, David R. Macdonald, Martin J. Van den Bent, and Susan M. Chang. “Application of novel response/progression measures for surgically delivered therapies for gliomas: Response Assessment in Neuro-Oncology (RANO) Working Group.Neurosurgery 70, no. 1 (January 2012): 234–43. https://doi.org/10.1227/NEU.0b013e318223f5a7.
Vogelbaum MA, Jost S, Aghi MK, Heimberger AB, Sampson JH, Wen PY, et al. Application of novel response/progression measures for surgically delivered therapies for gliomas: Response Assessment in Neuro-Oncology (RANO) Working Group. Neurosurgery. 2012 Jan;70(1):234–43.
Vogelbaum, Michael A., et al. “Application of novel response/progression measures for surgically delivered therapies for gliomas: Response Assessment in Neuro-Oncology (RANO) Working Group.Neurosurgery, vol. 70, no. 1, Jan. 2012, pp. 234–43. Pubmed, doi:10.1227/NEU.0b013e318223f5a7.
Vogelbaum MA, Jost S, Aghi MK, Heimberger AB, Sampson JH, Wen PY, Macdonald DR, Van den Bent MJ, Chang SM. Application of novel response/progression measures for surgically delivered therapies for gliomas: Response Assessment in Neuro-Oncology (RANO) Working Group. Neurosurgery. 2012 Jan;70(1):234–243.
Journal cover image

Published In

Neurosurgery

DOI

EISSN

1524-4040

Publication Date

January 2012

Volume

70

Issue

1

Start / End Page

234 / 243

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Practice Guidelines as Topic
  • Neurology & Neurosurgery
  • Neoplasm Recurrence, Local
  • Magnetic Resonance Imaging
  • International Cooperation
  • Humans
  • Glioma
  • Combined Modality Therapy
  • Brain Neoplasms