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Clinical applications of a peptide-based vaccine for glioblastoma.

Publication ,  Journal Article
Kanaly, CW; Ding, D; Heimberger, AB; Sampson, JH
Published in: Neurosurg Clin N Am
January 2010

Glioblastoma multiforme is a malignant, relentless brain cancer with no known cure, and standard therapies leave significant room for the development of better, more effective treatments. Immunotherapy is a promising approach to the treatment of solid tumors that directs the patient's own immune system to destroy tumor cells. The most successful immunologically based cancer therapy to date involves the passive administration of monoclonal antibodies, but significant antitumor responses have also been generated with active vaccination strategies and cell-transfer therapies. This article summarizes the important components of the immune system, discusses the specific difficulty of immunologic privilege in the central nervous system, and reviews treatment approaches that are being attempted, with an emphasis on active immunotherapy using peptide vaccines.

Duke Scholars

Published In

Neurosurg Clin N Am

DOI

EISSN

1558-1349

Publication Date

January 2010

Volume

21

Issue

1

Start / End Page

95 / 109

Location

United States

Related Subject Headings

  • Vaccines, Subunit
  • Vaccination
  • Neurology & Neurosurgery
  • Immunotherapy
  • Immunity
  • Immune Tolerance
  • Immune System
  • Humans
  • Glioblastoma
  • Epitopes
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kanaly, C. W., Ding, D., Heimberger, A. B., & Sampson, J. H. (2010). Clinical applications of a peptide-based vaccine for glioblastoma. Neurosurg Clin N Am, 21(1), 95–109. https://doi.org/10.1016/j.nec.2009.09.001
Kanaly, Charles W., Dale Ding, Amy B. Heimberger, and John H. Sampson. “Clinical applications of a peptide-based vaccine for glioblastoma.Neurosurg Clin N Am 21, no. 1 (January 2010): 95–109. https://doi.org/10.1016/j.nec.2009.09.001.
Kanaly CW, Ding D, Heimberger AB, Sampson JH. Clinical applications of a peptide-based vaccine for glioblastoma. Neurosurg Clin N Am. 2010 Jan;21(1):95–109.
Kanaly, Charles W., et al. “Clinical applications of a peptide-based vaccine for glioblastoma.Neurosurg Clin N Am, vol. 21, no. 1, Jan. 2010, pp. 95–109. Pubmed, doi:10.1016/j.nec.2009.09.001.
Kanaly CW, Ding D, Heimberger AB, Sampson JH. Clinical applications of a peptide-based vaccine for glioblastoma. Neurosurg Clin N Am. 2010 Jan;21(1):95–109.
Journal cover image

Published In

Neurosurg Clin N Am

DOI

EISSN

1558-1349

Publication Date

January 2010

Volume

21

Issue

1

Start / End Page

95 / 109

Location

United States

Related Subject Headings

  • Vaccines, Subunit
  • Vaccination
  • Neurology & Neurosurgery
  • Immunotherapy
  • Immunity
  • Immune Tolerance
  • Immune System
  • Humans
  • Glioblastoma
  • Epitopes