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Muscle autoantibodies in myasthenia gravis: beyond diagnosis?

Publication ,  Journal Article
Meriggioli, MN; Sanders, DB
Published in: Expert Rev Clin Immunol
July 2012

Myasthenia gravis is an autoimmune disorder of the neuromuscular junction. A number of molecules, including ion channels and other proteins at the neuromuscular junction, may be targeted by autoantibodies leading to abnormal neuromuscular transmission. In approximately 85% of patients, autoantibodies, directed against the postsynaptic nicotinic acetylcholine receptor can be detected in the serum and confirm the diagnosis, but in general, do not precisely predict the degree of weakness or response to therapy. Antibodies to the muscle-specific tyrosine kinase are detected in approximately 50% of generalized myasthenia gravis patients who are seronegative for anti-acetylcholine receptor antibodies, and levels of anti-muscle-specific tyrosine kinase antibodies do appear to correlate with disease severity and treatment response. Antibodies to other muscle antigens may be found in the subsets of myasthenia gravis patients, potentially providing clinically useful diagnostic information, but their utility as relevant biomarkers (measures of disease state or response to treatment) is currently unclear.

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Published In

Expert Rev Clin Immunol

DOI

EISSN

1744-8409

Publication Date

July 2012

Volume

8

Issue

5

Start / End Page

427 / 438

Location

England

Related Subject Headings

  • Receptors, Nicotinic
  • Receptors, Cholinergic
  • Receptor Protein-Tyrosine Kinases
  • Myasthenia Gravis
  • Muscle, Skeletal
  • Immunology
  • Humans
  • Autoimmune Diseases
  • Autoantigens
  • Autoantibodies
 

Citation

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Meriggioli, M. N., & Sanders, D. B. (2012). Muscle autoantibodies in myasthenia gravis: beyond diagnosis? Expert Rev Clin Immunol, 8(5), 427–438. https://doi.org/10.1586/eci.12.34
Meriggioli, Matthew N., and Donald B. Sanders. “Muscle autoantibodies in myasthenia gravis: beyond diagnosis?Expert Rev Clin Immunol 8, no. 5 (July 2012): 427–38. https://doi.org/10.1586/eci.12.34.
Meriggioli MN, Sanders DB. Muscle autoantibodies in myasthenia gravis: beyond diagnosis? Expert Rev Clin Immunol. 2012 Jul;8(5):427–38.
Meriggioli, Matthew N., and Donald B. Sanders. “Muscle autoantibodies in myasthenia gravis: beyond diagnosis?Expert Rev Clin Immunol, vol. 8, no. 5, July 2012, pp. 427–38. Pubmed, doi:10.1586/eci.12.34.
Meriggioli MN, Sanders DB. Muscle autoantibodies in myasthenia gravis: beyond diagnosis? Expert Rev Clin Immunol. 2012 Jul;8(5):427–438.
Journal cover image

Published In

Expert Rev Clin Immunol

DOI

EISSN

1744-8409

Publication Date

July 2012

Volume

8

Issue

5

Start / End Page

427 / 438

Location

England

Related Subject Headings

  • Receptors, Nicotinic
  • Receptors, Cholinergic
  • Receptor Protein-Tyrosine Kinases
  • Myasthenia Gravis
  • Muscle, Skeletal
  • Immunology
  • Humans
  • Autoimmune Diseases
  • Autoantigens
  • Autoantibodies