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Blood pressure as a predictor of cardiovascular events in the elderly: the William Hale Research Program.

Publication ,  Journal Article
Masley, SC; Phillips, SE; Schocken, DD
Published in: J Hum Hypertens
June 2006

This study evaluates the association between blood pressure (BP) and the risk of developing cardiovascular disease (CVD) events in the elderly. The Morton Plant Mease Foundation has followed 4,008 elderly patients >64 years of age for at least 5 years. Systolic and diastolic blood pressure (SBP and DBP) was divided into categories. Cardiovascular disease events were classified as myocardial infarction, stroke, and CVD-related deaths reported from the National Death Index. Cox proportional hazard ratios were used to assess the relationship between BP and CVD events and controlled for weight, gender, smoker, and alcohol use. Ages <75 and >or=75 years were assessed separately. After 11.1 years of follow-up, elevated SBP (P=<0.0001) is strongly associated with developing a future CVD event; the relationship is linear and graded and holds for ages above and below 75 years. The frequency of CVD events was lowest in the SBP <120 mm Hg group. In subjects <75 years of age, DBP elevations were not a significant risk factor for CVD events. (relative risk (RR): DBP 70 to <80 mm Hg=0.92; DBP 80 to <90 mm Hg=0.88; DBP >or=90 mm Hg=1.02.) With subjects >or=75 years of age, a DBP between 80 and 90 is associated with the lowest significant risk for CVD (RR: DBP 70 to <80 mm Hg=0.74; DBP 80 to <90 mm Hg=0.59; DBP >or=90=0.71). In conclusion, these findings support the Joint National Committee on Hypertension recommendations for SBP in the elderly. Further studies are warranted to identify optimal DBP for the elderly at various ages.

Duke Scholars

Published In

J Hum Hypertens

DOI

ISSN

0950-9240

Publication Date

June 2006

Volume

20

Issue

6

Start / End Page

392 / 397

Location

England

Related Subject Headings

  • Risk Assessment
  • Proportional Hazards Models
  • Predictive Value of Tests
  • Male
  • Humans
  • Florida
  • Female
  • Confounding Factors, Epidemiologic
  • Chi-Square Distribution
  • Cardiovascular System & Hematology
 

Citation

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Masley, S. C., Phillips, S. E., & Schocken, D. D. (2006). Blood pressure as a predictor of cardiovascular events in the elderly: the William Hale Research Program. J Hum Hypertens, 20(6), 392–397. https://doi.org/10.1038/sj.jhh.1002002
Masley, S. C., S. E. Phillips, and D. D. Schocken. “Blood pressure as a predictor of cardiovascular events in the elderly: the William Hale Research Program.J Hum Hypertens 20, no. 6 (June 2006): 392–97. https://doi.org/10.1038/sj.jhh.1002002.
Masley SC, Phillips SE, Schocken DD. Blood pressure as a predictor of cardiovascular events in the elderly: the William Hale Research Program. J Hum Hypertens. 2006 Jun;20(6):392–7.
Masley, S. C., et al. “Blood pressure as a predictor of cardiovascular events in the elderly: the William Hale Research Program.J Hum Hypertens, vol. 20, no. 6, June 2006, pp. 392–97. Pubmed, doi:10.1038/sj.jhh.1002002.
Masley SC, Phillips SE, Schocken DD. Blood pressure as a predictor of cardiovascular events in the elderly: the William Hale Research Program. J Hum Hypertens. 2006 Jun;20(6):392–397.

Published In

J Hum Hypertens

DOI

ISSN

0950-9240

Publication Date

June 2006

Volume

20

Issue

6

Start / End Page

392 / 397

Location

England

Related Subject Headings

  • Risk Assessment
  • Proportional Hazards Models
  • Predictive Value of Tests
  • Male
  • Humans
  • Florida
  • Female
  • Confounding Factors, Epidemiologic
  • Chi-Square Distribution
  • Cardiovascular System & Hematology