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Atrial natriuretic peptides increase calcitonin gene-related peptide within human circulation.

Publication ,  Journal Article
Vesely, DL; Overton, RM; McCormick, MT; Schocken, DD
Published in: Metabolism
July 1997

Long-acting natriuretic peptide (LANP), vessel dilator, and atrial natriuretic factor (ANF) (each infused at 100 ng/kg body weight [BW].min for 60 minutes) increased the circulating concentration of calcitonin gene-related peptide (CGRP) threefold to fourfold in 30 healthy humans. Within 30 minutes of stopping ANF infusion, the CGRP circulating concentration had returned to preinfusion levels, whereas its increase secondary to the other atrial peptides was still significant 2 to 3 hours after cessation of their infusions. There was a 50% decreased excretion (P < .001) of CGRP into the urine secondary to LANP and vessel dilator, which correlated with the increase of CGRP in the circulation. The ANF-induced 50% decreased CGRP excretion occurred after the circulating concentration of CGRP had returned to preinfusion levels. Kaliuretic peptide did not affect CGRP circulating concentration or excretion into urine. These data suggest that LANP and vessel dilator inhibit the metabolic breakdown of CGRP as part of their mechanism of increasing CGRP in plasma, whereas the ANF effect of increasing CGRP in plasma appears to be secondary to stimulating the release of CGRP.

Duke Scholars

Published In

Metabolism

DOI

ISSN

0026-0495

Publication Date

July 1997

Volume

46

Issue

7

Start / End Page

818 / 825

Location

United States

Related Subject Headings

  • Systole
  • Protein Precursors
  • Peptide Fragments
  • Middle Aged
  • Male
  • Kidney
  • Humans
  • Female
  • Endocrinology & Metabolism
  • Diastole
 

Citation

APA
Chicago
ICMJE
MLA
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Vesely, D. L., Overton, R. M., McCormick, M. T., & Schocken, D. D. (1997). Atrial natriuretic peptides increase calcitonin gene-related peptide within human circulation. Metabolism, 46(7), 818–825. https://doi.org/10.1016/s0026-0495(97)90129-3
Vesely, D. L., R. M. Overton, M. T. McCormick, and D. D. Schocken. “Atrial natriuretic peptides increase calcitonin gene-related peptide within human circulation.Metabolism 46, no. 7 (July 1997): 818–25. https://doi.org/10.1016/s0026-0495(97)90129-3.
Vesely DL, Overton RM, McCormick MT, Schocken DD. Atrial natriuretic peptides increase calcitonin gene-related peptide within human circulation. Metabolism. 1997 Jul;46(7):818–25.
Vesely, D. L., et al. “Atrial natriuretic peptides increase calcitonin gene-related peptide within human circulation.Metabolism, vol. 46, no. 7, July 1997, pp. 818–25. Pubmed, doi:10.1016/s0026-0495(97)90129-3.
Vesely DL, Overton RM, McCormick MT, Schocken DD. Atrial natriuretic peptides increase calcitonin gene-related peptide within human circulation. Metabolism. 1997 Jul;46(7):818–825.
Journal cover image

Published In

Metabolism

DOI

ISSN

0026-0495

Publication Date

July 1997

Volume

46

Issue

7

Start / End Page

818 / 825

Location

United States

Related Subject Headings

  • Systole
  • Protein Precursors
  • Peptide Fragments
  • Middle Aged
  • Male
  • Kidney
  • Humans
  • Female
  • Endocrinology & Metabolism
  • Diastole