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Amodiaquine and sulfadoxine-pyrimethamine as treatment for chloroquine-resistant Plasmodium falciparum in Rwanda.

Publication ,  Journal Article
Deloron, P; Sexton, JD; Bugilimfura, L; Sezibera, C
Published in: Am J Trop Med Hyg
March 1988

The efficacy of amodiaquine and sulfadoxine-pyrimethamine combination as a second-line therapy for chloroquine-resistant Plasmodium falciparum infections was investigated in Rwanda in September 1986. Children less than or equal to 5 years old presenting with a P. falciparum parasitemia 14 days after treatment with chloroquine were administered either amodiaquine (25 mg/kg over 3 days, 64 patients) or sulfadoxine-pyrimethamine (as a single dose with tablets containing 500 mg of sulfadoxine and 25 mg of pyrimethamine: 1/4 tablet for children under 1 year, 1/2 for those 1-3 years old, and 1 tablet for those 4-5 years old; 34 patients) and followed for 7 days. Seven days after starting treatment with amodiaquine, 50 (76%) children were aparasitemic. All the children who had received sulfadoxine-pyrimethamine were aparasitemic 7 days after initiation of therapy.

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Published In

Am J Trop Med Hyg

DOI

ISSN

0002-9637

Publication Date

March 1988

Volume

38

Issue

2

Start / End Page

244 / 248

Location

United States

Related Subject Headings

  • Tropical Medicine
  • Sulfanilamides
  • Sulfadoxine
  • Rwanda
  • Pyrimethamine
  • Plasmodium falciparum
  • Male
  • Malaria
  • Infant
  • Humans
 

Citation

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Deloron, P., Sexton, J. D., Bugilimfura, L., & Sezibera, C. (1988). Amodiaquine and sulfadoxine-pyrimethamine as treatment for chloroquine-resistant Plasmodium falciparum in Rwanda. Am J Trop Med Hyg, 38(2), 244–248. https://doi.org/10.4269/ajtmh.1988.38.244
Deloron, P., J. D. Sexton, L. Bugilimfura, and C. Sezibera. “Amodiaquine and sulfadoxine-pyrimethamine as treatment for chloroquine-resistant Plasmodium falciparum in Rwanda.Am J Trop Med Hyg 38, no. 2 (March 1988): 244–48. https://doi.org/10.4269/ajtmh.1988.38.244.
Deloron P, Sexton JD, Bugilimfura L, Sezibera C. Amodiaquine and sulfadoxine-pyrimethamine as treatment for chloroquine-resistant Plasmodium falciparum in Rwanda. Am J Trop Med Hyg. 1988 Mar;38(2):244–8.
Deloron, P., et al. “Amodiaquine and sulfadoxine-pyrimethamine as treatment for chloroquine-resistant Plasmodium falciparum in Rwanda.Am J Trop Med Hyg, vol. 38, no. 2, Mar. 1988, pp. 244–48. Pubmed, doi:10.4269/ajtmh.1988.38.244.
Deloron P, Sexton JD, Bugilimfura L, Sezibera C. Amodiaquine and sulfadoxine-pyrimethamine as treatment for chloroquine-resistant Plasmodium falciparum in Rwanda. Am J Trop Med Hyg. 1988 Mar;38(2):244–248.

Published In

Am J Trop Med Hyg

DOI

ISSN

0002-9637

Publication Date

March 1988

Volume

38

Issue

2

Start / End Page

244 / 248

Location

United States

Related Subject Headings

  • Tropical Medicine
  • Sulfanilamides
  • Sulfadoxine
  • Rwanda
  • Pyrimethamine
  • Plasmodium falciparum
  • Male
  • Malaria
  • Infant
  • Humans