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Nanoparticle based biological assays

Publication ,  Journal Article
Schultz, S; Mock, J; Smith, DR; Schultz, DA
Published in: Journal of Clinical Ligand Assay
June 1, 1999

An introduction to the utilization of plasmon resonant particles as optical labels for diverse biological applications is presented. Plasmon resonant particles (PRP(TM)) (Seashell Technology LLC, La Jolla, CA) are sub- micron (40-100 nanometer), ultra-bright, nonbleaching, multicolor, light scattering objects that can be attached to standard biomolecules. The basic concepts and use of PRP in various biological applications such as immunoassays and histology, including in-situ hybridization, and tissue labeling are discussed. We suggest that this new label will replace and/or complement the traditional labels presently used that are based on radioactivity, fluorescence, or chemiluminescence. Since the detection of each individual label is readily performed, the measured signal is a simple count of all of the detected labels. Thus, the ultimate sensitivity of the assay is set by both the degree of label binding to the individual 'target' molecular entity, and the corresponding number of labels that bind nondiscriminately.

Duke Scholars

Published In

Journal of Clinical Ligand Assay

ISSN

1081-1672

Publication Date

June 1, 1999

Volume

22

Issue

2

Start / End Page

214 / 216

Related Subject Headings

  • General Clinical Medicine
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Schultz, S., Mock, J., Smith, D. R., & Schultz, D. A. (1999). Nanoparticle based biological assays. Journal of Clinical Ligand Assay, 22(2), 214–216.
Schultz, S., J. Mock, D. R. Smith, and D. A. Schultz. “Nanoparticle based biological assays.” Journal of Clinical Ligand Assay 22, no. 2 (June 1, 1999): 214–16.
Schultz S, Mock J, Smith DR, Schultz DA. Nanoparticle based biological assays. Journal of Clinical Ligand Assay. 1999 Jun 1;22(2):214–6.
Schultz, S., et al. “Nanoparticle based biological assays.” Journal of Clinical Ligand Assay, vol. 22, no. 2, June 1999, pp. 214–16.
Schultz S, Mock J, Smith DR, Schultz DA. Nanoparticle based biological assays. Journal of Clinical Ligand Assay. 1999 Jun 1;22(2):214–216.

Published In

Journal of Clinical Ligand Assay

ISSN

1081-1672

Publication Date

June 1, 1999

Volume

22

Issue

2

Start / End Page

214 / 216

Related Subject Headings

  • General Clinical Medicine