Scholars@Duke publication: Substance P primes human neutrophil activation: a mechanism for neurological regulation of inflammation.

Substance P primes human neutrophil activation: a mechanism for neurological regulation of inflammation.

Publication , Journal Article

Perianin, A; Snyderman, R; Malfroy, B

Published in: Biochem Biophys Res Commun

June 15, 1989

The neuropeptide substance P (SP), a member of the tachykinin family, has stimulatory effects on various cell types at nanomolar concentrations. SP has also direct effects on polymorphonuclear leukocytes (PMNs). However, unlike other cells, stimulation of PMNs requires extremely high concentrations of the peptide (greater than 10 microM), suggesting that direct PMN activation by SP is not physiologically relevant. By measuring primed stimulation of PMNs, we now demonstrate potent synergistic effects of nanomolar doses of SP on the migratory and cytotoxic functions of human PMNs stimulated by fMLP and C5a. This synergism between SP and chemotactic peptides reveals a new regulatory activity of SP and suggests that neurogenic stimuli may prepare neutrophils for an exaggerated inflammatory response to other phlogistic mediators.

Duke Scholars

Author Ralph Snyderman Medicine

Published In

Biochem Biophys Res Commun

DOI

10.1016/0006-291x(89)92630-2

ISSN

0006-291X

Publication Date

June 15, 1989

Volume

161

Issue

Start / End Page

520 / 524

Location

United States

Related Subject Headings

Substance P
Oxygen Consumption
Neutrophils
N-Formylmethionine Leucyl-Phenylalanine
Inflammation
In Vitro Techniques
Humans
Drug Synergism
Complement C5a
Complement C5

Citation

APA

Chicago

ICMJE

MLA

NLM

Perianin, A., Snyderman, R., & Malfroy, B. (1989). Substance P primes human neutrophil activation: a mechanism for neurological regulation of inflammation. Biochem Biophys Res Commun, 161(2), 520–524. https://doi.org/10.1016/0006-291x(89)92630-2

Perianin, A., R. Snyderman, and B. Malfroy. “Substance P primes human neutrophil activation: a mechanism for neurological regulation of inflammation.” Biochem Biophys Res Commun 161, no. 2 (June 15, 1989): 520–24. https://doi.org/10.1016/0006-291x(89)92630-2.

Perianin A, Snyderman R, Malfroy B. Substance P primes human neutrophil activation: a mechanism for neurological regulation of inflammation. Biochem Biophys Res Commun. 1989 Jun 15;161(2):520–4.

Perianin, A., et al. “Substance P primes human neutrophil activation: a mechanism for neurological regulation of inflammation.” Biochem Biophys Res Commun, vol. 161, no. 2, June 1989, pp. 520–24. Pubmed, doi:10.1016/0006-291x(89)92630-2.

Perianin A, Snyderman R, Malfroy B. Substance P primes human neutrophil activation: a mechanism for neurological regulation of inflammation. Biochem Biophys Res Commun. 1989 Jun 15;161(2):520–524.