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Neisseria meningitidis bacteremia in association with deficiency of the sixth component of complement.

Publication ,  Journal Article
Lee, TJ; Snyderman, R; Patterson, J; Rauchbach, AS; Folds, JD; Yount, WJ
Published in: Infect Immun
June 1979

The serum of a 26-year-old black man with a recent episode of meningococcemia complicated by meningitis and arthritis was found to lack hemolytic complement activity. The sixth component of complement was not detected by functional or immunochemical assays whereas other components were normal by hemolytic assay. His fresh acute-phase serum lacked complement-mediated bactericidal activity against the homologous strain of Neisseria meningitidis, but the addition of fresh normal serum or purified C6 restored bactericidal activity as well as hemolytic activity. The absence of C6 activity could not be accounted for on the basis of an inhibitor. Opsonization and chemotaxis functioned normally. Histocompatibility typing of family members did not demonstrate evidence for genetic linkage of C6 deficiency with the major histocompatibility loci. This report represents the first published case of C6 deficiency associated with bacteremic Neisseria infections in which antimeningococcal bactericidal antibodies have been definitively demonstrated against the homologous strain in the acute phase of the illness.

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Published In

Infect Immun

DOI

ISSN

0019-9567

Publication Date

June 1979

Volume

24

Issue

3

Start / End Page

656 / 660

Location

United States

Related Subject Headings

  • Sepsis
  • Phagocytosis
  • Opsonin Proteins
  • Neisseria meningitidis
  • Microbiology
  • Meningitis, Meningococcal
  • Male
  • Major Histocompatibility Complex
  • Humans
  • Histocompatibility Testing
 

Citation

APA
Chicago
ICMJE
MLA
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Lee, T. J., Snyderman, R., Patterson, J., Rauchbach, A. S., Folds, J. D., & Yount, W. J. (1979). Neisseria meningitidis bacteremia in association with deficiency of the sixth component of complement. Infect Immun, 24(3), 656–660. https://doi.org/10.1128/iai.24.3.656-660.1979
Lee, T. J., R. Snyderman, J. Patterson, A. S. Rauchbach, J. D. Folds, and W. J. Yount. “Neisseria meningitidis bacteremia in association with deficiency of the sixth component of complement.Infect Immun 24, no. 3 (June 1979): 656–60. https://doi.org/10.1128/iai.24.3.656-660.1979.
Lee TJ, Snyderman R, Patterson J, Rauchbach AS, Folds JD, Yount WJ. Neisseria meningitidis bacteremia in association with deficiency of the sixth component of complement. Infect Immun. 1979 Jun;24(3):656–60.
Lee, T. J., et al. “Neisseria meningitidis bacteremia in association with deficiency of the sixth component of complement.Infect Immun, vol. 24, no. 3, June 1979, pp. 656–60. Pubmed, doi:10.1128/iai.24.3.656-660.1979.
Lee TJ, Snyderman R, Patterson J, Rauchbach AS, Folds JD, Yount WJ. Neisseria meningitidis bacteremia in association with deficiency of the sixth component of complement. Infect Immun. 1979 Jun;24(3):656–660.

Published In

Infect Immun

DOI

ISSN

0019-9567

Publication Date

June 1979

Volume

24

Issue

3

Start / End Page

656 / 660

Location

United States

Related Subject Headings

  • Sepsis
  • Phagocytosis
  • Opsonin Proteins
  • Neisseria meningitidis
  • Microbiology
  • Meningitis, Meningococcal
  • Male
  • Major Histocompatibility Complex
  • Humans
  • Histocompatibility Testing