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BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary.

Publication ,  Journal Article
Kirilly, D; Spana, EP; Perrimon, N; Padgett, RW; Xie, T
Published in: Developmental cell
November 2005

BMP signaling is essential for promoting self-renewal of mouse embryonic stem cells and Drosophila germline stem cells and for repressing stem cell proliferation in the mouse intestine and skin. However, it remains unknown whether BMP signaling can promote self-renewal of adult somatic stem cells. In this study, we show that BMP signaling is necessary and sufficient for promoting self-renewal and proliferation of somatic stem cells (SSCs) in the Drosophila ovary. BMP signaling is required in SSCs to directly control their maintenance and division, but is dispensable for proliferation of their differentiated progeny. Furthermore, BMP signaling is required to control SSC self-renewal, but not survival. Moreover, constitutive BMP signaling prolongs the SSC lifespan. Therefore, our study clearly demonstrates that BMP signaling directly promotes SSC self-renewal and proliferation in the Drosophila ovary. Our work further suggests that BMP signaling could promote self-renewal of adult stem cells in other systems.

Duke Scholars

Published In

Developmental cell

DOI

EISSN

1878-1551

ISSN

1534-5807

Publication Date

November 2005

Volume

9

Issue

5

Start / End Page

651 / 662

Related Subject Headings

  • Wnt1 Protein
  • Stem Cells
  • Signal Transduction
  • Proto-Oncogene Proteins
  • Ovary
  • Models, Biological
  • Longevity
  • Gene Expression Regulation, Developmental
  • Female
  • Drosophila Proteins
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kirilly, D., Spana, E. P., Perrimon, N., Padgett, R. W., & Xie, T. (2005). BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary. Developmental Cell, 9(5), 651–662. https://doi.org/10.1016/j.devcel.2005.09.013
Kirilly, Daniel, Eric P. Spana, Norbert Perrimon, Richard W. Padgett, and Ting Xie. “BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary.Developmental Cell 9, no. 5 (November 2005): 651–62. https://doi.org/10.1016/j.devcel.2005.09.013.
Kirilly D, Spana EP, Perrimon N, Padgett RW, Xie T. BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary. Developmental cell. 2005 Nov;9(5):651–62.
Kirilly, Daniel, et al. “BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary.Developmental Cell, vol. 9, no. 5, Nov. 2005, pp. 651–62. Epmc, doi:10.1016/j.devcel.2005.09.013.
Kirilly D, Spana EP, Perrimon N, Padgett RW, Xie T. BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary. Developmental cell. 2005 Nov;9(5):651–662.
Journal cover image

Published In

Developmental cell

DOI

EISSN

1878-1551

ISSN

1534-5807

Publication Date

November 2005

Volume

9

Issue

5

Start / End Page

651 / 662

Related Subject Headings

  • Wnt1 Protein
  • Stem Cells
  • Signal Transduction
  • Proto-Oncogene Proteins
  • Ovary
  • Models, Biological
  • Longevity
  • Gene Expression Regulation, Developmental
  • Female
  • Drosophila Proteins