Attenuation of the neurotoxic effect of A beta amyloid peptide by apolipoprotein E.
Publication
, Journal Article
Whitson, JS; Mims, MP; Strittmatter, WJ; Yamaki, T; Morrisett, JD; Appel, SH
Published in: Biochem Biophys Res Commun
February 28, 1994
Alzheimer's disease patients have increased frequency of apolipoprotein E allele c4, suggesting apoE4 is a risk factor determining disease. ApoE binds A beta amyloid peptide with great avidity in vitro and in the neuritic plaque. Potentially, binding of A beta to apolipoprotein E could increase A beta neurotoxicity. However, in hippocampal cultures, 0.1 microM apolipoprotein E eliminated the neurotoxicity of 10 microM A beta. Neuronal rescue was dose-dependent and occurred even after 48 hours exposure to A beta, but was overwhelmed by excess A beta. Thus, interaction between these proteins does not directly increase A beta neurotoxicity, and the role of ApoE in Alzheimer's disease remains to be elucidated.
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Published In
Biochem Biophys Res Commun
DOI
ISSN
0006-291X
Publication Date
February 28, 1994
Volume
199
Issue
1
Start / End Page
163 / 170
Location
United States
Related Subject Headings
- Rats, Sprague-Dawley
- Rats
- Protein Binding
- Neurotoxins
- In Vitro Techniques
- Hippocampus
- Cell Survival
- Biochemistry & Molecular Biology
- Apolipoproteins E
- Animals
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Whitson, J. S., Mims, M. P., Strittmatter, W. J., Yamaki, T., Morrisett, J. D., & Appel, S. H. (1994). Attenuation of the neurotoxic effect of A beta amyloid peptide by apolipoprotein E. Biochem Biophys Res Commun, 199(1), 163–170. https://doi.org/10.1006/bbrc.1994.1209
Whitson, J. S., M. P. Mims, W. J. Strittmatter, T. Yamaki, J. D. Morrisett, and S. H. Appel. “Attenuation of the neurotoxic effect of A beta amyloid peptide by apolipoprotein E.” Biochem Biophys Res Commun 199, no. 1 (February 28, 1994): 163–70. https://doi.org/10.1006/bbrc.1994.1209.
Whitson JS, Mims MP, Strittmatter WJ, Yamaki T, Morrisett JD, Appel SH. Attenuation of the neurotoxic effect of A beta amyloid peptide by apolipoprotein E. Biochem Biophys Res Commun. 1994 Feb 28;199(1):163–70.
Whitson, J. S., et al. “Attenuation of the neurotoxic effect of A beta amyloid peptide by apolipoprotein E.” Biochem Biophys Res Commun, vol. 199, no. 1, Feb. 1994, pp. 163–70. Pubmed, doi:10.1006/bbrc.1994.1209.
Whitson JS, Mims MP, Strittmatter WJ, Yamaki T, Morrisett JD, Appel SH. Attenuation of the neurotoxic effect of A beta amyloid peptide by apolipoprotein E. Biochem Biophys Res Commun. 1994 Feb 28;199(1):163–170.
Published In
Biochem Biophys Res Commun
DOI
ISSN
0006-291X
Publication Date
February 28, 1994
Volume
199
Issue
1
Start / End Page
163 / 170
Location
United States
Related Subject Headings
- Rats, Sprague-Dawley
- Rats
- Protein Binding
- Neurotoxins
- In Vitro Techniques
- Hippocampus
- Cell Survival
- Biochemistry & Molecular Biology
- Apolipoproteins E
- Animals