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Marrow transplantation from unrelated donors for treatment of hematologic malignancies: effect of mismatching for one HLA locus.

Publication ,  Journal Article
Beatty, PG; Anasetti, C; Hansen, JA; Longton, GM; Sanders, JE; Martin, PJ; Mickelson, EM; Choo, SY; Petersdorf, EW; Pepe, MS
Published in: Blood
January 1, 1993

One hundred twelve patients less than 36 years old received marrow grafts from unrelated donors as treatment for hematologic malignancy. Seventy donor/recipient pairs were phenotypically identical for HLA-A, -B, and -D, while 42 had a "minor" disparity at one HLA locus. There was an increase in the risk of acute graft-versus-host disease (GVHD) in patients receiving HLA-partially matched grafts compared with those receiving HLA-matched grafts (51% v 36% probability of grades III-IV acute GVHD). However, in this cohort of patients, there was no significant difference in survival (at 1.5 years, 46% v 51% for good-risk patients, 44% v 30% for poor-risk patients). This finding suggests that some degree of HLA disparity can be tolerated in young patients transplanted from unrelated donors for malignant disease, thus making transplantation an option available to larger numbers of patients.

Duke Scholars

Published In

Blood

ISSN

0006-4971

Publication Date

January 1, 1993

Volume

81

Issue

1

Start / End Page

249 / 253

Location

United States

Related Subject Headings

  • Tissue Donors
  • Survival Rate
  • Risk Factors
  • Neoplasm Recurrence, Local
  • Leukemia
  • Immunology
  • Humans
  • Histocompatibility Testing
  • Histocompatibility
  • HLA Antigens
 

Citation

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Beatty, P. G., Anasetti, C., Hansen, J. A., Longton, G. M., Sanders, J. E., Martin, P. J., … Pepe, M. S. (1993). Marrow transplantation from unrelated donors for treatment of hematologic malignancies: effect of mismatching for one HLA locus. Blood, 81(1), 249–253.
Beatty, P. G., C. Anasetti, J. A. Hansen, G. M. Longton, J. E. Sanders, P. J. Martin, E. M. Mickelson, S. Y. Choo, E. W. Petersdorf, and M. S. Pepe. “Marrow transplantation from unrelated donors for treatment of hematologic malignancies: effect of mismatching for one HLA locus.Blood 81, no. 1 (January 1, 1993): 249–53.
Beatty PG, Anasetti C, Hansen JA, Longton GM, Sanders JE, Martin PJ, et al. Marrow transplantation from unrelated donors for treatment of hematologic malignancies: effect of mismatching for one HLA locus. Blood. 1993 Jan 1;81(1):249–53.
Beatty PG, Anasetti C, Hansen JA, Longton GM, Sanders JE, Martin PJ, Mickelson EM, Choo SY, Petersdorf EW, Pepe MS. Marrow transplantation from unrelated donors for treatment of hematologic malignancies: effect of mismatching for one HLA locus. Blood. 1993 Jan 1;81(1):249–253.

Published In

Blood

ISSN

0006-4971

Publication Date

January 1, 1993

Volume

81

Issue

1

Start / End Page

249 / 253

Location

United States

Related Subject Headings

  • Tissue Donors
  • Survival Rate
  • Risk Factors
  • Neoplasm Recurrence, Local
  • Leukemia
  • Immunology
  • Humans
  • Histocompatibility Testing
  • Histocompatibility
  • HLA Antigens